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Compression and Compaction压片技术（FMC）
Section 3
Compression/Compaction
By Dr. Keith Marshall
Table of Contents
Compression/Compaction 1
Table of Contents 1
General Introduction4
The Pros and Cons of Tablets4
The Sophisticated Tablet4
Some Important Properties of Powders Intended for Tablets 5
Deformation5
Effect of Massive Extended Forces 7
Compression 7
Consolidation 8
Die Compaction (Tableting) 8
Simple Tablet Press Cycle8
System Geometry 11
Force-Time Profiles 11
Compressibility12
Heckel Plots 12
Density Distributions in Compacts13
Frictional Effects14
Load Removal and Tablet Ejection 15
Removal of Applied Load15
Ejection15
Consolidation Potential 16
Compaction Force Versus Tablet Strength 16
Energy Involved in Compaction 17
Work of Compaction 18
Analysis of Force-Displacement Curves18
The Tableting Process19
Introduction to Tablet Presses 19
Tablet Machine Design20
Single-Station Presses20
Multi-Station Presses 20
Contemporary Tableting Process23
High Production Rates 24
High Turret Speed 24
Precompression 25
Cams 25
1
Feeders26
Lubrication27
Increased Number of Stations 27
Turret Web 28
Multi-Sequence Presses 28
Multi-Tipped Tooling28
Ancillary Equipment 29
Tablet Tooling 30
Punches30
The Hob30
Matched Tooling30
Inspection30
Tablet Problems31
Release Profile31
Weight Variation31
Content Uniformity 32
Mechanical Strength Problems32
Capping and Lamination33
Chipping34
Stress Cracking34
Picking34
Rate of Compaction (Press Speed)35
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