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为了克服上述缺陷Yang等建立了一种在活体内可连续重复
Human U-87-RFP glioma growing in brain of nude mouse. Whole-body image. Brain cancer models?Features Orthotopic transplantation Green Fluorescent Protein expression Red Fluorescent Protein expression Orthotopic transplantation of intact tissue? Metastatic sites ?????????????????? lymph nodes ?????????????????? liver ?????????????????? lung ????????????????? skeleton? Estrogen-dependent? Estrogen-independent? Green Fluorescent Protein expression? Red Fluorescent Protein expression MX-1-GFP and –RFP breast carcinoma growing on mammary fat pads of SCID mouse. Whole-body image. Breast cancer models ?Features Human LOX-1-GFP melanoma metastasized to lung (A), lymp node (B), bone (C) and adrenal gland (D) of nude mouse. Melanoma modelsFeatures Orthotopic transplantation of intact tissue Metastatic sites ?????????????????? lymph nodes ?????????????????? lung ???????????????????skeleton ?????????????????? brain ?????????????????? kidney? ????????????????? adrenal glands Lung cancer modelsFeatures Orthotopic transplantation of intact tissue Metastatic sites ?????????????????? lymph nodes ?????????????????? contralateral lung ?????????????????? kidney ??????????????????? skeleton ?????????????????? esophagus ?????????????????? diaphragm? ?????????????????? brain ?????????????????? heart Small-Cell Carcinoma? Non-Small Cell Carcinoma? Adenocarcinoma? Green Fluorescent Protein expression PC-3 human carcinoma growing on prostate and metastasized to numerous lymph nodes of nude mouse. Whole-body image. Prostate cancer models? Features Orthotopic transplantation of intact tissue Metastatic sites ?????????????????? lymph nodes ?????????????????? liver ?????????????????? lung ?????????????????? skeleton Green Fluorescent Protein expression Red Fluorescent Protein expression NUGC-4-GFP human stomach tumor in nude mouse. Primary tumor- red arro
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