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叉头框Fox转录因子家族的结构与功能-生命科学
18 5 Vol. 18, No. 5
2006 10 Chinese Bulletin of Life Sciences Oct., 2006
1004-0374(2006)05-0491-06
(Fox)
200433
(forkhead boxFox) DNA
17 Fox
PI3K-Akt/PKBTGFβ-Smad
MAP Kinase Fox Fox
Q51; Q523 A
The structure and function of forkhead (Fox) transcription factor family
CAO Dong-Mei, LU Jian*
(Department of Pathophysiology, Academy of Basic Medicine, Second Military Medical University,
Shanghai 200433, China)
Abstract: Forkhead box (Fox) proteins characterized by a conserved winged-helix DNA binding domain
constitute a large family of transcription factors. Fox proteins regulate the gene transcription not only by
recruiting various coactivators like most transcription factors, some members of this family but also by binding
to the condensed chromosomes directly, which can remodel chromatin structure and generate a combinatorial
effect with other transcription factors to cause significant changes in expression. PI3K-Akt/PKBTGFβ-
Smad and MAP Kinase signal pathways regulate the activity of Fox proteins via phosphorylation reaction. The
diverse biological processes that Fox proteins influence, such as embryonic development, cell cycle regulation,
glucose and lipid metabolism, aging and immunoregulation, have also been covered in this article.
Key words: transcription factors; forkhead box (Fox); molecular structure; transcription activation; function
(forkhead boxFox) D N A
- - 92%
1989 Weigel DNA
(fkh) DNA
100 Fox
17 FoxO
Lai FoxA C L M P Fox
HNF-3AWeigel Jäckle[1]HNF-3A Fkh
2006-02-10 2006-03-22
( 1 9 7 7 ) ( 1 9 5 3 )
*
492
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