糖尿病脂代谢紊乱推荐.ppt

M1 - Anorexia nervosa:神经性厌食 Bulimia：贪食症 Thiazide diuretics：噻嗪类利尿药 Retinoids：视黄醛 Androgens：雄激素 Background Type 2 (non-insulin-dependent) diabetes is associated with a marked increase in the risk of coronary heart disease. It has been debated whether patients with diabetes who have not had myocardial infarctions should be treated as aggressively for cardiovascular risk factors as patients who have had myocardial infarctions. Methods To address this issue, we compared the seven-year incidence of myocardial infarction (fatal and nonfatal) among 1373 nondiabetic subjects with the incidence among 1059 diabetic subjects, all from a Finnish population-based study. Results The seven-year incidence rates of myocardial infarction in nondiabetic subjects with and without prior myocardial infarction at base line were 18.8 percent and 3.5 percent, respectively (P0.001). The seven-year incidence rates of myocardial infarction in diabetic subjects with and without prior myocardial infarction at base line were 45.0 percent and 20.2 percent, respectively (P0.001). EBT , a noninvasive diagnosis of CAD before clinical presentation asymptomatic diabetic persons have the same atherogenic burden of those patients with CAD without diabetes. The high prevalence of CC in asymptomatic persons with diabetes supports the need for aggressive management of diabetes and associated risk factors. EBT: electron beam tomography CC: coronary calcium Am Heart J 141(4): 637-644, 2001 Post-CABG: Effect of Aggressive Lipid Lowering on Progression in a Diabetic Subgroup The Post Coronary Artery Bypass Graft study (Post-CABG) randomized individuals with prior CABG to either aggressive lovastatin therapy or moderate lovastatin therapy. The LDL cholesterol levels achieved in the respective groups were 95 mg/dL versus 135 mg/dL. In the overall paper, there was a significant slowing of angiographic progression of atherosclerosis in saphenous vein grafts in the high-dose lovastatin group compared with th