肌松药与拮抗药推荐.ppt

Company Logo 静脉输注100mg/kg半胱氨酸后血流动力学变化 可见到一个急性的MAP的下降，之后出现一个更为持久的升高。伴有小幅度的心率改变以及体循环血管阻力、心排出量、左心室射血分数等多相改变。 （但所有的改变都属于在这个研究中定义为临床不显著的范围中 ） 苄异喹啉类肌松拮抗剂（Sunaga等狗研究） Company Logo 给予100mg/kg的半胱氨酸产生小幅度但持续的MAP的波动等 神经节阻滞剂：可能出现初始的MAP下降，但对继发的持久上升没有影响 相反，给予抗利尿激素V1-受体拮抗剂消除了持久小幅度的血压升高反应 苄异喹啉类肌松拮抗剂（Sunaga等狗研究） Company Logo Two approaches towards idea muscle relaxant To find Better NMBAs Better reversal agents GW280430A G-1-64 TAAC3 SZ1677 AV002 Sugammadex Cysteine/Glutathione ywf808@ Weifeng Yu, MD,PHD Professor, The Department of Anesthesiology,Eastern Hepatobiliary Surgery Hospital,SMMU SHANGHAI * Tetrodotoxin 河豚毒素 batrachotoxin 蛙毒素 hemicholinium botulinus toxin 肉毒杆菌毒素 fampridine curare alkaloids 箭毒生物碱 decamethonium 十烃季铵 veratridine 藜芦定 quinine 奎宁 * * * Nobel Prize * Endplate Ach receptor 20 Angstroms. Also propose how Ach fits the sites. * Long molecules bend. CAR and future drug design. * Anything in the horizon? * SZ1677 similar to Rap and Miv in duration of action. * SZ1677 similar to Rap and Miv in duration of action. * SZ1677 similar to Rap and Miv in duration of action. * SZ1677 similar to Rap and Miv in duration of action. * Explain gamma cyclo dextrin. * Holes differ in size. * * In the following 4 scenes the mechanisms by which neuromuscular function, blockade, and reversal take place will be depicted. The main purpose of these animations is to demonstrate the novelty and superiority of encapsulation using Bridion versus traditional reversal with cholinesterase inhibitors. This first scene shows the manner in which normal neuromuscular function takes place. As you can see, the acetylcholine (shown in blue) is released from the nerve axon into the synaptic cleft. From there, the acetylcholine binds to the nicotinic acetylcholine receptor on the muscle endplate. Once there is a sufficient number acetylcholine receptors are filled, a electrical depolarization of the postjunctional membrane takes place. T