早期家庭干预促进新生儿缺氧缺血性脑病患儿智力发育的临床观察.doc

早期家庭干预促进新生儿缺氧缺血性脑病患儿智力发育的临床观察 中国康复医学杂志,2004年,第19卷,第2期ChineJournalof— RehabilitationMedicine,Feb. — 2004,Vo1.19,No.2123 ? 论着? 早期家庭干预促进新生儿缺氧缺血性脑病患儿 智力发育的临床观察 赵萍周春梅张伟忠张坤尧郭秀东严文康 摘要目的:探讨早期干预对新生儿缺氧缺血性脑病(HIE)患儿智力及运动发育的影响.方法:将82例HIE患儿分 为干预组40例,对照组42例;仅干预组接受早期干预,两组患儿接受相同的育儿知识,由专人定期进行体格发育与 神经系统检查及智力测定.结果:干预组在1岁和2岁时智力发育指数(MDI)为98.6+17.2,104.1+_13,7,运动发育指 数(PDI)为89.3+_12.8,95.4_+12.1,明显高于对照组MDI:88.9+_10.5,93.4+_14,4和PDI:80.8±9.4,86.3+_15.2),差异有显 着性(Plt;O.01);干预组中脑瘫,智力低下,癫痫发生例数明显低于对照组,差异亦有显着性(Plt;O.01),但两组在体格发 育方面比较差异无显着性(Pgt;O.05).结论:对HIE患儿进行早期干预可改善其智力及运动发育,减少伤残,降低脑 瘫,癫痫的发生率. 关键词新生儿;缺氧缺血性脑病;早期干预;智力;运动发育;促进 Clinicaleffectofearlyinterventionfortheinfantswithhypoxic-ischemicencephalopathy/ZHAOPing, ZHOUChunmei,ZHANGWeizhong,eta1.//ChineseJournalofRehabilitationMedicine,2004,19(2):123--125 AbstractObjective:Tostudytheclinicaleffectofearlyinterventiononintelligentialandphysicaldevelopmentof hypoxic—ischemicencephalopathy(HIE)infants.Method:82infantswithHIEweredividedintointerventiongroup(40 cases)andcontralgroup(42cases).Earlyinterventionwasonlyappliedintheinterventiongroup.Allcasesaccepted thesameeducation.Thephysicalandneurologicalconditionsandintelligencetestwerestudiedregularyly.Result: Attheageof1yearand2yearininterventiongroup,thementaldevelopmentindex(MDI)was98.6+_17.2and 104.1+_13.7.thepsychomotivedevelopmentindex(PDI)was89.3+_12,8and95.4+_12.1.Theyweresignificantilyhigher thanthoseofthecontralgroupMDI:88.9±10.5,93.4±14.4.PDI:80.8±9.4,86.3±15.2lt;0.01).Theincidenceof cerebralpalsy,disabilityandepilepsyintheinterventiongroupwassignificantlylowerthanthatinthecontral groupfPlt;0.01).Therewasnosignificantlydifferenceofmitordevelopmentinthetwogroupsff】gt;0,05).Conclusion: EarlyinterventionintheinfantswithHIEcanimprovetheirintelligentialandmotordevelopment,reducethe incidenceofdisability,cerebralpalsyandepilepsy, AuthorSaddressDept.ofPediatrics,HuizhouPeopleSCentralHospital,GuangdongProvince,Huizhou,516001 Keywordsinfants;hypoxic—ischemicencephalopathy;earlyintervention;intelligen