稀土配合物对藤黄微球菌抑制作用的热动力学分析及其配方组建-化学工程专业论文.docx

摘要农业生产中出现的病虫害对常用的杀菌剂产生了不同程度的抗药性，使得防治效果明显下 降。因此制备新型高效、低毒病原菌的抑菌剂用于农作物病虫害的防治追在眉睫。基于稀土盐和 二苯羧酸类配体的抑菌活性，本文主要完成以下工作。采用水热法和溶液法，以4，4’．二羧基二苯基砜(H2SDBA)为配体，在稀土金属的协同作用 下，合成六种Ln．H2(SDBA)配合物；以4，4’．二羧基二苯基醚(H20BA)为配体与稀土盐反应， 合成八种Ln．H2(OBA)配合物。通过元素分析、摩尔电导率、红外光谱、紫外光谱、X射线粉末 衍射、以及TG．DTG等手段对配合物的组成结构和物理化学性质进行表征。采用微量热法，实时跟踪监测上述制备的稀土配合物对藤黄微球菌生长代谢的抑制作用，获 得热谱图。通过热动力学模型对热谱图进行解析，计算出生长和抑制过程的各种热动力学函数， 得到细菌生长速率常数(k)、最大产热功率(Pm舣)、传代时间(TG)以及抑制率(I)等热动力 学参数。揭示配合物的抑菌效果，明晰配合物结构和抑菌效果间的相互关系，抑菌配合物作用机 理。以配合物[Sm2(SDBA)3饵20)4(DMF)2】·H20为代表，通过微量热实验对乳化剂、润湿剂、分散 剂等助剂的种类和用量进行筛选，组建抑菌剂基础配方。最终确定抑菌剂基础配方的组成及摩尔 含量：配合物0．2‰乳化剂十二烷基苯磺酸钙1．5‰润湿剂十二烷基硫酸钠1．5％，分散剂木质素磺酸钠2．0％，DMF 25％-40％，水补足100％。本论文为此类配合物抑菌剂的研究提供热力学 基础和理论依据，为功能配合物农药研究提供一种新的思路。关键词：稀土配合物，微量热法，藤黄微球菌，抑菌剂万方数据AbstractThe diseases and pests of plants appear different drug resistance for common bactericides in agriculture，leading to the prevention decreased obviously．In order to prevent and control the diseases and pests of plants，it is very essential to synthesis the new bacteriostatic agent with hi曲efficiency,low toxicity．Based on the antibacterial activity of rare earth salts and dibenzene carboxylic acid ligand，the main contents of thiS work are as follow．By using hydrothermal and solution reactions，six Ln(111)-based complexes with 4,4-dicarboxy diphenyl sulfone and eight Ln(III)-based complexes、)l，itll 4，4’-dicarboxy diphenyl ether have been synthesized，respectively．The structures and physicochemical properties of these complexes obtainted above have been characterized by elemental analyses，infrared spectrum，UV-Vis spectrum，X-ray powder diffraction,and TG-DTG．The calorimetry is used tO detect the bacteriostasis on Micrococcus luteus derived from the titlecomplexes and further receive thermograms which are analyzed by thermal dynamic model，obtaining the thermodynamic functions in the processes of growth and inhibition,and the thermodynamicparameters of growth rate constant∞，maximum heat power of growth phase㈨，generation time(To)and inhibitory ratio(I)．Thus，the antibacter