酪氨酸衍生物的合成及其凝胶性能研究-应用化学专业论文.docx

Subject: Synthesis and Gelation Properties of Tyrosine Derivatives Specialty: Applied ChemistryName: Ma Xiaodan（signature） Instructor : Zhou AnningLiYuangang（signature） ABSTRACTLow-molecular-mass organic gels (LMOG) have numerous potential practical applications in preparation of nano materials, environmental management, drug delivery, etc, which is due to their completely thermal reversibility, special self-assembly, stimuli-responsible and other properties. It is an important research direction in this field how to design and synthesize simple gelator molecules, easy to synthesize and available in large quantities from cheap starting materials, and study the relation between their structure and gel performance.In this thesis, new tyrosine-based gelators were designed and synthesized. The relation between gelation properties and the structure of these tyrosine-based molecules, as well as the morphology and molecular packing fashion of LMOG were studied. On this basis, the BDT hydrogel have been investigated in the ?eld of drug delivery.The results from TLC, 1H-NMR and FTIR analysis confirmed that new Tyrosinederivatives, namly, Boc-O-docyl-L-tyrosine (BDT), didodecyl-L- tyrosine methyl ester-1,6-adipamide (TEDHB), didodecyl L-tyrosine-1,6-adip- amide (TDHB), Boc-O-docyl-L-tyrosine methyl ester (BDTE) and docyl-L- tyrosine methyl ester (DTE) had been synthesized from cheap and renewable Boc-L-tyrosine methyl ester at room temperature.The gelation behavior of five Tyrosine derivatives, namly, BDT, TEDHB, TDHB, BDTE and DTE was systematically studied in eighteen different common solvents. The results showed that TEDHB could gel alkane solvents, DMSO and vegetable oil; TDHB could gel benzene, and could gel trichloromethane under ultrasound assistance; TDHB and BDT could form pH-sensitivity hydrogel. Though these tyrosine derivatives had a little difference in structure, their gelling behavior was significant different.The minimal gelation concentration (MGC) of TEDHB