Neuroleptic Drugs精神病药物.pptVIP

Neuroleptic Drugs Antischizophrenic Drugs Antipsychitic Drugs Tranquilizers * * Classification of Symptoms of Schizophrenia Positive Symptom Negative Symptom Agitation Insomnia Delusions Apathy (avolition) Disorganized speech Affective flattening Disorganized thinking Lack of motivation Hallucinations Lack of pleasure Poverty of speech Social isolation? Classification of Neuroleptic Drugs Typical neuroleptic (low potensy) Typical neuroleptic (high potensy)  Atypical neuroleptic  Typical neuroleptic (low potensy)(Dopamine receptor antagonists) Chlorpromazine ProchlorperazinePromethazineThioridazineFluphenazine 氯氮平 氟派啶醇 吗茚酮 利培酮 替沃噻吨 Typical neuroleptic (high potensy)(Dopamine receptor antagonists)FluphenazineHaloperidolPimozideThiothixene Atypical neuroleptic(Block serotonin receptors)AripiprazoleClozapineOlanzapineQuetiapineZiprasidone Single photon emission tomography After therapy with typical neuroleptic drugs After therapy with atypical neuroleptic drugs Dopamine-blocking action of neuroleptic drugsD1 and D5 AC↑D2, D3, D4 AC↓ Relative affinity of drugs at D1 and D2 receptorsextrapyramidal side effectsdopamine agonists Neuroleptic drugs block at dopamine receptors and serotonergic receptors as well as at other receptors. Adverse effects commonly observed in in individuals treated with neuroleptic drugs. Antidepressant drugs Depression is a serious disorderr that afflicts approximately 14 million adults in the USA. The life time prevalence rate of depression in the USA has been estimated to include 16% of adults (21% women,