毕业设计（论文）--重复测量方差分析在临床试验中的应用.doc

毕业设计（论文）中文摘要 题目 重复测量方差分析在临床试验中的应用 摘要： 重复测量数据的方差分析是对同一变量进行重复测的试验设计重复测量是指对同一观察对象的某项观测指标在不同时间点上进行多次测量，用于分析观指标在不同时间上的变化规律 方差分析 临床试验 SPSS软件 毕业设计（论文）外文摘要 Title Application of Repeated Measure ANONA in The Clinical Trials Abstract The repeated measure ANONA is an experimental design technology for the repeated measure of the same dependent variable, and it is a method often applied in the biostatistics. Repeated measures refer to data with multiple records over time on the same subject with the objective of making inference about the expected value of outcomes, in terms of treatment effects and how such effects change over time. Repeated measurements arise frequently in biomedical research, the scientific question of interest concerns finding differences in the measurements between groups. In this paper, the repeated measure ANONA was used to analyzing the expression of vascular endothelial growth factor(VEGF) among patients of meconium aspiration syndrome, who received drug treatment of pulmonary surfactant. Also this paper introduced how to apply SPSS software to conduct data analysis. The results show that application of pulmonary surfactant treatment of meconium aspiration syndrome by inhibiting VEGF levels to improve the vascular endothelial permeability, slow down the disease progresses. Keywords： Repeated measure ANONA Clinical trials SPSS 目 次 1 绪论………………………………………………………………………………… 1 1.1 重复测量的定义………………………………………………………………… 1 1.2重复测量方差分析的应用条件………………………………………………… 2 1.3 重复测量设计的优缺点………………………………………………………… 4 1.4重复测量方差分析的应用方法………………………………………………… 4 1.5重复测量方差分析的研究现状……………………………………………… 5 1.6论文的研究内容………………………………………………………………… 6 2 SPSS软件的简介及研究现状……………………………………………………… 6 2.1 SPSS软件的简介………………………………………………………………… 6 2.2 SPSS软件的研究现状…………………………………………………………… 8 3 临床资料的重复测量方差分析…………………………………………………… 8 3.1 资料来源和分组………………………………………………………………… 8 3.2 统计学方法……………………………………………………………………… 9 3.3 应用SPSS软件实现重复测量方差分析的步骤及结果……………………… 10 3.4 讨论……………………………………………………………………………… 18 结论 ……………………………………