系列讲座之二十一(Prof.Yang Zhen).ppt

Introduction of the Laboratories Strategy Contents Proposed Biogenetic Pathway of Micrandilactone Family Second Generation of Retrosynthetic Analysis Enyne Ring-Closing Metathesis Approach Contents Approach 2: Retrosynthetic Analysis Epoxidation SmI2 Mediated Reductive Ring-closure Reaction -1 Contents Synthesis of the Key Intermediate 9 The Thiourea-Pd and Thiourea-Co Catalyzed Carbonylative Annulations Ring-closing Metathesis (RCM) to Form the 16-Membered Lactone of Epothelones Formation of Two-type of Pd-Thiourea Complexes Equilibrium between Monomer and Dimer Synthesis of Bidentate Ligands and Their Pd-Complexes Type II: Thiourea-Pd Complex Catalyzed Suzuki and Suzuki-Carbonylative Coupling Reactions Type III: Thiourea-Pd Complex Catalyzed Heckand Diazonium based Heck Coupling Reactions Platform for the Syntheses of Thiourea-based Ligands The Thiourea-Transition Metals Catalyzed Reactions Co-TMTU Catalyzed Hetero-Pauson-Khand Reaction Study for the Thiourea-Pd Catalyzed Annulation Proposed Mechanism for the Formation of 10 and 11 Contents Model Study on the B-C-E-D-F Pentacyclic System Challenging Synthetic Concert Total Synthesis Previous Experience for Total Synthesis Acknowledgment Zebrafish for Chemical Genomics Compound Screening Transgenic Zebrafish at Beida Epoxidation Taxol Brevetoxin A Epothilone A Zaragozic Acid A ￥ National Science Foundation of China ￥ Ministry of Education of China $ VivoQuest Inc. and XTL Biopharmaceuticals through a sponsored research program Ye-Feng Tang, Yan-Dong Zhang, Lu-Jiang Deng Tou-Ping Luo; Ming-Ji Dai, Guang-Bin Dong ? Prof. Jia-Hua Chen, Prof. Guo-Xin Wang Outlook Stereoselective Synthesis of FGH Ring System Stereoselective Synthesis of ABC Ring System Synthetic Analysis Background Introduction Developed Novel Synthetic Methodologies for the Stereoselective Synthesis of FGH Ring System Ligand Development ? C P N Sulfur-based Ligands S A new complex of palladium-thiourea and carbon tetrabr