贺福初院士 蛋白质组学课件.ppt

OUTLINE Background Progress Next Task OUTLINE Background Progress Next Task HUPO Workshop, Bethesda, April 28-29, 2002 Broad interests and supports for initiating HLPP HUPO Liver Proteome Workshop, Beijing, October 22-24, 2002 Getting consensus view for scientific objectives of HLPP HUPO 1st World Congress, Versailles, November 21-24, 2002 Co-chairs of HLPP: Drs. Fuchu He, John Bergeron and Christian Bréchot HLPP Planning Committee: 17 members; May 2003 Proposals about Working Plan of HLPP Dr. John Bergeron: Jan 31, 2003 (Management); Dr. Fuchu He: Feb 17, 2003 (Scientific Strategy) Dr. Fuchu He: Mar 22, 2003 (Action Plan); Dr. Christian Brechot: Mar 31, 2003 (Sampling) HLPP Office, March 18, 2003 HUPO LPP Workshop, Bethesda, July 17-18, 2003 NIH participating HUPO 2nd World Congress, Montreal, Oct. 8-12, 2003 Dr. Fuchu He was appointed as the executive Chair of HLPP (2003-2005) HUPO HLPP Satellite Meeting, Montreal, Oct.12, 2003 Set up Executive Committee 9 Sub-committees, Action Plan at Pilot Phase Actions at Pilot Phase 2003-2005 Organize global work team Set up management structure and global communications 2. Form Standard Operating Procedures (SOPs) 3. Generate specimen bank 4. Construct and evaluate platforms 5. Develop HLPP informatics infrastructure 6. Complete primary expression profile of health liver proteins 8. Generate 1000 antibodies against liver protein 9. Other activities OUTLINE Background Progress Next Task Human fetal liver is a major site of fetal hematopoiesis, and a developing hepatic organ. Preview of Expression Profile with Human Fetal LiverSystems Biology Labs, BIRMFuchu HeXiaohong QianYunping Zhu Analytical strategies Criteria for the process of mass spectrometric data Protein Database:IPI_human_2.33 MALDI-TOF-TOF/ ESI-QTOF MS  Mascot () 9