GPCRpresentation091304-中国药科大学药物筛选课件.pdf

Development of Novel Cell-Based Assays and Screening Tools for G Protein-Coupled Receptors Matthew H. Hsu, Ph.D. Chemicon International, Inc. TOOLS FOR DRUG DISCOVERY Towards Proprietary Bioassay Systems for High Throughput Screening RNA and Stable Cell Native/Stable Native/Stable cDNA Library Lines Cell Lines Cell Lines G G SAR U MOLECULAR SAR U MOLECULAR Target Primary Target Primary HITS LEADS Validation Screen HITS o o LEADS R TARGETS Validation Screen o o R TARGETS 2 /3 Screen 2 /3 Screen D D Pharmacologically Molecular Molecular HTS Assays characterized cell Tools Tools base assays We offer tools for 1st and 2nd screens and HTSAR Over 60% of the Currently Marketed Drugs Are Targeted to GPCRs Cost to develop a drug today is over HTS Target Types $800 million, and no company has the capacity (chemists) to launch Other needed number of projects each year