hcv感染实验动物模型的研究进展 姜晨晨，彭宗根 （中国医学科学院.docVIP

HCV感染动物模型 姜晨晨，彭宗根 （中国医学科学院医药生物技术研究所100050） [] 丙型肝炎病毒（HCV）感染是导致肝硬化和肝癌的最主要病因黑猩猩是HCV感染的最佳实验动物，但由于其来源有限、价格昂贵及等诸多问题，其应用受限，因此发展新的实验动物模型用于HCV基础研究迫在眉。近年来，以啮齿类动物为替代模型取得了不少进展，应用转基因等实验技术感染了HCV，并应用于多个领域研究。本文 HCV自然感染的实验动物的替代实验动物优缺点。 [] 丙型肝炎病毒；替代实验动物模型；啮齿类动物 xperimental animal models for the research of HCV infection JIANG Chen-chen, PENG Zong-gen (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing100050, China) [Abstract] Hepatitis C virus (HCV) is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma in humans. Due to the lack of suitable experimental animal models for HCV infection, the development of more effective treatment of HCV infection and vaccines has been delayed. Chimpanzee is the best experimental animal model for the research of hepatitis C virus (HCV) infection. But because of its limited in resource, expensive in breeding, and difference in clinical symptoms, thus developing new experimental animal models for HCV-related basic and applied research is imminent. In recent years, as a surrogate animal model, the development of rodent model and other models has been achieved ??a lot of progress. Using such as genetically modified experimental techniques, those surrogate animals were infected with HCV in vivo and were successfully applied to the research in several areas. In this review, we will focus on the achieved progress in natural infected animal model and transgenic surrogate experimental model, and their advantage and limitation in usage in study on the pathogenic mechanism of infection, drug evaluation and the development of vaccines, and will also discuss the future direction of development of experimental animal models for research of infection with HCV. [Key words] Hepatitis C virus；Natural infected animal models；Surrogate animal models；Rodents [基金项目] 国家自然科学基金委优秀青年科学基金；教育部新世纪优秀人才项目（NCET-12-0072）；北京市科技新星项目（2010B072） [作者简介] 姜晨晨，女，硕士研究生，研究方向：抗病毒药物药理学研究。E-mail: ha