人参皂苷的代谢产物总结 澳门科技大学.pptVIP

A brief review of ginsenosidesmetaboltes Chen chengyu Outline Structure of ginsenosides Protopanaxadiol(PPD) groups Protopanaxatriol(PPT) groups Possible pathway of ginsenosides in vivo PPD groups PPT groups Metabolites of ginsenosides PPD groups PPT groups Structure of PPT groups ginsenosides Possible pathway of protopanaxadiol groups ginsenosides in vivo Metabolites of Ppd ginsenosides Rh2 deglycosylated: Ppd oxygenated: monooxygenated Rh2*, monooxygenated Ppd* hydroxylated: 26-hydroxy-Rh2 Metabolites of Ppd ginsenosides Rd oxygenated: monooxygenated Rd (oxygenation at 3 different sites) *, deglycosylated: Rb1, isomer of Rb1 *, Rg3, Rh2 Rb1 deglycosylated: Rd, Rg3, F2, Rh2, C-K, Ppd, isomer of Rd oxygenated: monooxygenated Rb1*, dioxygenated Rb1*, Both: monooxygenated Rh2*, monooxygenated C-K*, monooxygenated Ppd* Rb1 Polymerized: combined Rb1 (at 2 different sites)* Others: 12-β-hydroxydammar-3-ene-20(S)-O-D-Glc 25-hydroxyl-(E)-20(22)-ene-Rg3, 20(22),24-diene-Rg3, 25-hydroxy-Rd, Rh1, 25-hydroperoxy-23-ene-Rb1 Metabolites of Ppd ginsenosides Rb2 deglycosylated: Rd, F2, C-K, Rg3 20-O-[α-L-Araf (1---6)-β-D-Glu]-20(S)-Ppd， 3-O-β-D-Glu-20-O-[α-L-Araf (1---6)-β-D-Glu]-20(S)-Ppd，20(R)-Rg3, others: 25-hydroxy-23-ene-Rb2，24-hydroxy-25-ene-Rb2, 25-hydroperoxy-23-ene-Rb2, 24-hydroperoxy-23-ene-Rb2 Metabolites of Ppt ginsenosides Rh1 deglycosylated: Ppt oxygenated: monooxygenated Rh1 (at 2 different sites)* Re deglycosylated: Rg2, Rh1, 20-(R)-Rh1, F1, Ppt others: 3-oxo-Rh1, hydrated Rg2, Ppd Metabolites of Ppt ginsenosides Rg1 deglycosylated: Rh1, 20-(R)-Rh1, F1, Ppt others: hydrated Rh1, 25-hydroxy-Rh1, Rh4 * Structure of PPD groups ginsenosides -H -H Ppd -GlcAra -H Mc -GlcAra -Glc Mb -H -Glc Rh2 -Glc -H C-K -H -GlcGlc Rg3 -Glc -Glc F2 -GlcArap -GlcGlc Rc -Glc -GlcGlc Rd -GlcAraf -GlcGlc Rb2 -GlcGlc -GlcGlc Rb1 -GlcGlcXyl -GlcGlc Ra3 R2 R1