动脉硬化、性激素与骨质疏松的相关性研究论文.docVIP

异，而在骨量减少组与骨质疏松之间则无差异性存在。2.根据骨密度 检查结果，将人群分为骨量正常、骨量减少、骨量正常三组，比较性 激素在三组间的差异，结果发现雌二醇、睾酮、游离睾酮的水平在三 组之间均呈递减趋势，并且雌二醇、游离睾酮在骨量正常组与其他两 组比较时存在着差异，在骨量减少组与骨质疏松组之间没有统计学意 义，睾酮的水平在任何组间均未达到统计学意义。3. 将 181 例老年 男性根据 IMT 值分为 IMT1.0 组和 IMT1.0 组（包括 1.0），再比较 性激素水平在两组之间的差异。结果发现雌二醇、睾酮、游离睾酮的 水平在 IMT1.0 组均低于 IMT1.0 组，但是未达到统计学意义（雌二 醇、睾酮、游离睾酮的 P 值分别为 0.61、0.39、0.36）。4. 测定 181 例老年人的骨钙素、25-（OH）D3、尿 NTX 等，分析它们在骨量正常 组、骨量减少组、骨质疏松组之间的差异，结果发现三个指标在三组人 群中呈现逐渐改变的趋势，其中 25-（OH）D3、尿 NTX 有统计学意义（P 值分 别为 0.047、0.043、0.039），而骨钙素未达到统计学意义（P 值为 0.35）。 结论：1.颈动脉硬化与骨密度的高低有关，动脉 IMT 值与骨密度 呈负相关。2.雌二醇、游离睾酮的水平与骨密度的高低有关，与动脉 硬化的关系不显著，但是睾酮的水平与骨密度及动脉硬化的关系无统 计学意义。3. 骨量正常组、骨量减少组、骨质疏松组之间的骨钙素、 25-（OH）D3、尿 NTX 呈现逐渐改变的趋势。 关键词：动脉硬化，骨质疏松，性激素，骨代谢 2 THE STUDY OF THE OSTEOPOROSIS ,SEX HORMON AND ARTERIOSCLEROSIS ABSTRACT  Objectives:1.To  observe  the  relationship  between  osteoporosis  and  arteriosclerosis  2.To  analyze  the  relationship  between  sex  hormone(E2,TT,FT)  and  osteoporosis.3.To  investigate  the  difference  of  serum  biochemical  indicator  and  bone  metabolism  index  among  osteoporosis、osteopenia and normal groups. Method:1.230 people( ≥ 65 years) were divided into osteoporosis group ,osteopenia group and normal group .To compare the IMT among the three groups and approach the  relationship  between  the  osteoporosis  and  the  arteriosclerosis.2.181 female(≥65 years) were divided into osteoporosis group、osteopenia group and normal group .They were determined serum sex hormone、BMD and IMT. Compare the sex hormone among the three groups.3. 181 female(≥65 years) were divided into IMT0.8 group and IMT0.8（include 0.8）group. Comparing the sex hormone between the two groups.4. 181 female( ≥ 65 years) were divided into osteoporosis group、 osteopenia group and normal group. To investigate the difference of serum biochemical indicator and bone metabolism index among the three groups. 3 Result:1.On the basis of the BMD ,people were devided into  two  groups  :the  bone  mass