固尔苏联合CPAP治疗早产儿呼吸窘迫综合征临床研究.docVIP

固尔苏联合CPAP治疗早产儿呼吸窘迫综合征临床研究 　　[摘要] 目的 探讨固尔苏联合持续正压通气（CPAP）治疗早产儿呼吸窘迫综合征（NRDS）的临床疗效。方法 对照组患儿单纯使用CPAP治疗；研究组患者在对照组治疗方法基础上联合使用固尔苏；对两组患儿治疗前后血气指标及疗效进行比较分析。结果 研究组患者经治疗48h的总有效率88.89%明显高于对照组77.78%，死亡率5.56%，明显低于对照组11.11%（P＜0.05）；治疗后研究组pH、PaO2、PaO2/FiO2明显高于对照组，PaCO2明显低于对照组，数据经统计学比较具有显著差异（P＜0.05）。结论 联合使用固尔苏和CPAP治疗NRDS取得了良好的临床疗效，对于尽快提高患儿动脉氧分压、改善呼吸功能具有积极作用。 　　[关键词] 固尔苏；CPAP；早产儿呼吸窘迫综合征 　　[中图分类号] R722.6 [文献标识码] B [文章编号] 1673-9701（2011）34-57-02 　　 　　Clinical Study of Curosurf and Continuous Positive Airway Pressure Treating in Neonatal Respiratory Distress Syndrome 　　JIN Yinglan 　　The Peoples Hospital of Dongyang City，Zhejing Province， Dongyang 322100，China 　　 　　[Abstract] Objective To discuss the clinical effects of curosurf and continuous positive airway pressure（CPAP）treating in neonatal respiratory distress syndrome （NRDS）. Methods Children in control group were treated by CPAP，and children in study group were treated by curosurf combined with CPAP. Separately recording and analyzing the blood gas indexes and clinical effects before and after treatment. Results The total effective rates of study group 88.89% was significantly higher than control group 77.78% after treatment 48 hours（P＜0.05）. The pH、PaO2、PaO2/FiO2 of study group were significantly higher than control group and the PaCO2 were significantly higher than control group at any detection time after treatment（P＜0.05）. Conclusion The methods of curosurf combined with CPAP treating in NRDS has good clinical effects，which could effectively improve the PaCO2 and children’s respiratory function. 　　[Key words] Curosurf；Continuous positive airway pressure；Neonatal respiratory distress syndrome 　　 　　呼吸窘迫综合征（respiratory distress syndrome，RDS）在临床早产儿治疗与护理中较常见，也是导致早产儿死亡的重要因素之一。据统计患儿胎龄越小，其RDS的发病???越高[1]，危害极大。持续正压通气（continuous positive airway pressure，CPAP）是临床治疗早产儿RDS的有效方法，通过机械通气的方法能够有效调整患儿呼吸功能，提高通气量，减少血氧缺失而造成的各类并发症的发病率。近些年来，有研究将固尔苏与CPAP联合对早产儿呼吸窘迫综合征（NRDS）进行治疗并取得较好效果[2]。笔者选取我院2010年1～12月发生RDS的早产儿共36例进行临床治疗观察，以印证和探讨固尔苏联合CPAP的临床