坎地沙坦与培哚普利治疗老年高血压病疗效观察.docVIP

坎地沙坦与培哚普利治疗老年高血压病疗效观察 　　[摘要] 目的:探讨坎地沙坦联合苯磺酸氨氯地平治疗老年高血压病的疗效、安全性及对代谢指标的影响。方法:老年高血压病患者单独服用苯磺酸氨氯地平片5 mg/d,2周后血压未降至150/90 mm Hg以下者70例,随机分为两组,坎地沙坦联合组36例,每日晨加服坎地沙坦8 mg;培哚普利联合组34例,每日晨加服培哚普利4 mg,两组疗程均为8周,观察联合用药前后动态血压变化,血尿酸及胱抑素-C变化。结果:第8周末,两组血压水平均较分组前降低(P0.05)。两组血尿酸及胱抑素-C水平均较观察前降低(P 　　[关键词] 老年;高血压;坎地沙坦;培哚普利;平滑指数 　　[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210(2010)06(b)-053-04 　　 　　Effects of Candesartan compared with Perindopril in elderly hypertensive patients 　　WEI Qingmei1, CHEN Huanzhen2* 　　(1.Shanxi Medical University, Taiyuan030001, China; 2.The First Hospital of Shanxi Medical University, Taiyuan 030001, China) 　　[Abstract] Objective: To evaluate the safety and efficacy of Candesartan plus Amlodipine Besylate in elderly patients with hypertension. Methods: The elderly patients with hypertension took Amlodipine Besylate 5 mg daily alone. After two weeks treatment, 70 cases with blood pressure over 150/90 mm Hg were randomly divided into two groups,36 cases of Candesartan group treated with Candesartan 8 mg daily; 34 cases of Perindopril group treated with Perindopril 4 mg daily, they were treated for 8 weeks, the ambulatory blood pressure, blood uric acid and cystatin-C of two groups were compared. Results: After 8 weeks treatment, the blood pressure of two groups reduced, the differences were statistically significant (P0.05). In the two groups, the blood uric acid and cystatin-C were lower than those before treatment (P0.05),具有可比性。 　　1.2 药物及器械 　　苯磺酸氨氯地平,辉瑞公司生产,商品名:络活喜,5 mg/片,批号坎地沙坦,天津武田药品工业有限公司生产,商品名:必洛斯,8 mg/片,批号:980223;培哚普利,施维雅(天津)制药有限公司生产,商品名:雅施达,4 mg/片,批号:960470。动态血压为北京美高仪软件技术有限公司产品。 本文为全文原貌 未安装PDF浏览器用户请先下载安装 原版全文 　　1.3 方法 　　取得患者同意,入选后停用原降压药物,改服苯磺酸氨氯地平5 mg每日1次,晨服。2周后血压未降至150/90 mm Hg以下者随机分为两组,行动态血压监测、血生化检测,设置06∶00～22∶00为白昼,30 min测血压1次,22∶00～06∶00为夜间,每小时测血压1次。记录每次监测血压数值、报告计算全天平均血压、白昼平均血压、夜间平均血压,检出全天、白昼及夜间最高血压和最低血压。生化指标检测:检测当日06∶00～08∶00采空腹(空腹8 h以上)静脉血,送生化室检测,Roche P800自动生化检测仪,胱抑素-C(CYS-C)使用免疫浊度法(宁波美康生物有限公司生产)、尿酸(UA)等均为酶法(中生北控生物科技股份有限