奥扎格雷钠与丁咯地尔注射液治疗椎-基底动脉供血不足疗效观察.docVIP

奥扎格雷钠与丁咯地尔注射液治疗椎-基底动脉供血不足疗效观察 　　[摘要] 目的 探讨奥扎格雷钠与丁咯地尔注射液治疗椎-基底动脉供血不足的疗效及安全性。方法 将确诊的100例患者随机分成治疗组（奥扎格雷钠与丁咯地尔+丹参）及对照组（丹参）两组，用药后观察比较两组疗效及治愈时间；两组治疗前后椎基底动脉系统TCD时间平均流速的变化情况。结果 治疗组总有效率为92.0%，明显高于对照组（P＜0.05）。治疗组平均治愈时间明显短于对照组（P＜0.05）。治疗组左椎动脉TAV、右椎动脉TAV、基底动脉TAV治疗后较对照组改善明显。结论 奥扎格雷钠与丁咯地尔注射液治疗椎-基底动脉供血不足疗效确切，值得临床推广。 　　[关键词] 椎-基底动脉供血不足；丁咯地尔；奥扎格雷钠；TCD 　　[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2011）34-69-02 　　 　　The Efficacy of Ozagrel Combined with Buflomedil Injection in Treatment of Vertebral - Basilar Artery Insufficiency 　　YIN Changhao LI Siou LI Jingchao 　　Mudanjiang Medical College Redflag Hospital, Mudanjiang 157003, China 　　 　　[Abstract] Objective To investigate the efficacy and safety of ozagrel combined Buflomedil injection in treatment of vertebral - basilar artery insufficiency. Methods All of 100 patients were randomly divided into treatment group (with Ozagrel Buflomedil + SM) and the control group(SM) groups, to observe the efficacy and healing time; two groups before and after treatment of vertebral average basilar artery TCD velocity changes. Results The total effective rate was 92.0%, significantly higher （P＜0.05）. Treatment group, the average healing time was significantly shorter than the control group （P＜0.05）. Treatment group in the left vertebral artery TAV, the right vertebral artery TAV, TAV basilar artery after treatment than the control group improved more significantly. Conclusion Ozagrel and BUFLOMEDIL injection in the treatment of vertebral - basilar artery insufficiency is effective, worthy of promotion. 　　[Key words] Vertebral - basilar artery insufficiency; Buflomedil; Ozagrel; TCD 　　 　　椎-基底动脉供血不足是神经科的常见病、多发病，临床表现复杂多样，目前治疗主要为采取针对病因的对症治疗[1]。我科2009年12月~2010年12月应用奥扎格雷钠与丁咯地尔注射液治疗椎-基底动脉供血不足50例，取得了较好的效果，现报道如下。 　　 　　1 资料与方法 　　1.1 临床资料 　　选择我院2009年12月~2010年12月收治的100例作为观察对象，排除脑梗死、出血及肿瘤所致的眩晕。其中男60例，女40例，年龄48~76岁，平均（56.25±3.63）岁。将100例入选对象随机分成治疗组和对照组各50例。两组患者的性别、年龄等临床资料比较，差异无统计学意义（P＞0.05），具有可比性。见表1。 　　1.2 治疗方法 　　原有疾病者继续用原治疗药物，如控制高血压、高血糖，维持水电解