奥氮平与碳酸锂对躁狂发作疗效及生存质量对照研究.docVIP

奥氮平与碳酸锂对躁狂发作疗效及生存质量对照研究 　　【摘要】 目的 比较奥氮平与碳酸锂治疗对躁狂发作患者的疗效及对生存质量的影响。方法 采用入院顺序分层随机法,将120例躁狂发作患者平均分为研究组(奥氮平)和对照组(碳酸锂),在治疗前,治疗后1、2、4、6月末分别用Bech-Rafaelsen躁狂量表(BRMS)和临床疗效总评量表(CGI)及副反应表(TESS)评定疗效和不良反应,WHOQ0L-BREF量表衡量患者的生存质量,分析量表中各领域的计分。结果 两组BRMS总分在治疗后与治疗前比较有显著性差异(P0.05),碳酸锂组不良反应比奥氮平组多。 经6个月治疗,研究组的生理领域、心理领域、社会关系领域、环境领域的分值分别为(80.71±6.92),(93.67±4.23),(95.14±3.34),(93.16±2.45),对照组的生理领域、心理领域、社会关系领域、环境领域的分值分别为(79.35±7.97)、(83.92±5.28)、(82.52±4.56)、(80.65±3.85)。治疗后两组患者生存质量较治疗前均有显著改善(P 　　【关键词】躁狂发作;奥氮平;碳酸锂;疗效; 生存质量 　　 　　AControl study of Olanzapine and Lithium carbonatson efficacy and quality of exist in Manice pisode 　　 　　LI Xiao-xin,SUNQun-xing,LIU Yong,et al.Zhumadian Mental Hospital,Zhumadian 463000, China 　　 　　【Abstract】 ObjectiveTo observe the efficacy and quality of exist of olanzapine and lithium carbonas in the theatment of mannic episode.Methods Being used the random control study.120 manic episode were divided into study group(olanzapine)and countrol graup(lithium carbonas) randomly.Effects and side effects were assessed witn BRMS , CGI and TESS respectively before treatment and after1、2、4、6 months. WHOQ0L-BREF instruments were used to evaluate the patients quality of exist before and after drug abministration. by menas of analyzing the scores in every domains.Results Two set with total BRMS before treat after with treat relatively showed the difference of with on significance(P0.05). The side effects were more in magnesium valproates group than those in lithium carbonas group. 6 months after treatment, the scores of physical health, psychological health, social relationship, and environment in study group were 80.71±6.92,9.67±4.23,95.14±3.34,93.16±2.45, and the scores of physical halth, psychological health, cocial relationship, and environment in control group were 79.35±7.97、83.92±5.28、82.52±4.56、80.65±3.85。and the scores of four domains in WHOQ0L-BREF instruments had been improved significantly in to groups (P13分; ④排除其他神经疾病、糖尿病、心、肝、肺、肾等躯体疾病史,无药物依赖及妊娠期,哺乳期患者; ⑤