川芎嗪对胎儿生长受限孕妇血液流变学影响.docVIP

川芎嗪对胎儿生长受限孕妇血液流变学影响 　　[摘要] 目的 探讨川芎嗪治疗对胎儿生长受限（FGR）孕妇血液流变性的影响。 方法 将34例FGR孕妇随机分为川芎嗪组17例（A组）和营养支持组17例（B组），另选择同期在我院定期产检并分娩的正常孕妇30例作为正常妊娠对照组（C组）。A组给予营养支持的同时加用川芎嗪注射液治疗，B组仅予以单纯营养支持治疗，7 d为1个疗程；C组除建议左侧卧位外，不予以其他处理。监测三组孕妇血液流变学参数、脐动脉血流及新生儿出生体重。 结果 治疗后，A组孕妇血液流变学参数、脐血流阻力明显低于B组，差异有统计学意义（P 　　[关键词] 川芎嗪；胎儿生长受限；血液流变学 　　[中图分类号] R714 [文献标识码] A [文章编号] 1673-7210（2012）02（b）-0051-04 　　 　　The impaction of Tetramethylpyrazine on hemorheology of pregnant woman with fetal growth restriction 　　ZHANG Zhenge1 WANG Yan2 　　1.Department of Obstetrics and Gynecology, the Central Hospital of Jingzhou City, Hubei Province, Jingzhou 434020, China; 2.Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Hubei Province, Wuhan 430071, China 　　[Abstract] Objective To assess the impaction of Tetramethylpyrazine on hemorheology of pregnant woman with fetal growth restriction (FGR). Methods 34 cases of pregnant women with FGR were randomly divided into Tetramethylpyrazine group (group A) and nutritional support group (group B), each group had 17 cases. Besides, 30 normal pregnant women who taken regular inspection at the corresponding time were selected as the control group (group C). Group A was treated with Tetramethylpyrazine combined with nutritional support for 7 days, group B was only given the nutritional support therapy, and group C was suggested to keep left-lateral position without any other treatment. Parameters such as maternal hemorheology, umbilical artery blood flow velocity, newborn birth weight were measured and compared among the three groups. Results After treatment the value of hemorheology parameters and umbilical artery blood flow resistance indexes of group A were significantly reduced than those of group B, the differences were statistically significant (P 0.05），其中，各组孕龄偏于36周的均不超过3例，具有可比性。见表1、2。 　　1.2 诊断标准[3-4] 　　①核实孕龄，???第6版《妇产科学》孕龄计算方法，校正所有入选孕妇的孕龄。②动态监测宫高增长速度：连续3周测量宫高在标准曲线第10百分位数以下，或增长缓慢或停滞不升，或计算胎儿生长发育指数=宫高（cm）-3×（月份＋1），胎儿生长发育指数 0.05）