某院2006~2010年抗铜绿假单胞菌药物敏感性分析.docVIP

某院2006~2010年抗铜绿假单胞菌药物敏感性分析 　　[摘要] 目的 了解抗铜绿假单胞菌检出情况及其对常用抗菌药物的药敏动态变化，为临床合理选用抗菌药物提供依据。 方法 应用回顾性调查方法，对江西省人民医院临床微生物室2006年1月～2010年12月各类临床标本分离的铜绿假单胞菌，采用纸片扩散法（K-B法）进行体外药敏试验，并对其数据进行分析。 结果 亚胺培南、头孢吡肟、头孢他啶、哌拉西林、环丙沙星对铜绿假单胞菌总敏感率均高于60%；头孢哌酮钠/舒巴坦、阿米卡星、哌拉西林/他唑巴坦对铜绿假单胞菌总敏感率均高于70%。头孢哌酮钠/舒巴坦、哌拉西林/他唑巴坦药物敏感率呈部分上升趋势；亚胺培南、头孢他啶、左氧氟沙星药物敏感率呈部分下降趋势。 结论 头孢他啶、头孢哌酮/舒巴坦及亚胺培南对铜绿假单孢菌仍保持较高的敏感性，但敏感率有逐年降低的趋势；含β-内酰胺抑制剂的β-内酰胺类复方制剂抗菌药物敏感性高，比单一β-内酰胺类抗菌活性更强。临床治疗应密切注意耐铜绿假单胞菌的药物监测，合理选用抗菌药物，以防止药物敏感性下降，降低临床药物疗效。 　　[关键词] 铜绿假单胞菌；抗菌药物；药物敏感性；合理用药 　　[中图分类号] R96 [文献标识码] C [文章编号] 1674-4721（2012）03（c）-0174-03 　　 　　Study of the susceptibility of drugs against pseudomonas aeruginosa during 2006 to 2010 in one hospital 　　JIANG Li1 CHEN Hui2 　　1.Department of Pharmacy, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang 330006, China; 2.Department of Clinical Laboratory, Jiangxi Provincial People′s Hospital, Nanchang 330006, China 　　[Abstract] Objective To investigate the detection of resistance to pseudomonas aeruginosa (P. aeruginosa) and the drug sensitivity dynamic changes of commonly used antibacterial drugs in order to provide the basis for the rational reference of clinical antibiotics. Methods P. aeruginosa were isolated from clinical specimens with the disc diffusion method (K-B) to have drug susceptibility test in vitro in clinical microbiology laboratory of Jiangxi Peoples Hospital from Jan. 2006 to Dec. 2010. The data of the test were analyzed by the retrospective investigation method. Results The results of the susceptibility test indicated that the total sensitivity ratios of imipenem, cefepime, ceftazidime, piperacillin, ciprofloxacin against P. aeruginosa were all above 60%. Those of cefoperazone sodium/shu TAZ, amikacin, piperacillin/tazobactam were all above 70%. The total sensitivity ratios of cefoperazone sodium/shu TAZ, piperacillin/tazobactam had a rising trend and that of imipenem, ceftazidime, levofloxacin a downward trend. Conclution Though ceftazidime, cefoperazone sodium/shu