脑泰通颗粒对缺血性脑卒中模型大鼠slit及vegf影响实验的研究.docx

statistically significant difference（P＜0.05）.③ At 7d, 10d, 14d timepoints, the VEGF protein content of experimental group were more thanpositive control group, they existed statistically significant difference（P＜0.05）. At 21d, 28d time points, the VEGF protein content of experimentalgroup were more than positive control group ,however, they did not existstatistically significant difference（P＞0.05）.④ Pathological sliceshowed: necrosis area of the experimental group and the positive controlgroup were all less than the placebo group at 7 day, we found that thecapillaries around ischemic area all increased at 21 day, experimental groupand the positive control group did not exist significant difference.Conclusion：After focal cerebral ischemia in rats, the expression ofSlit2 and VEGF increased,but they increased significantly because of takingdrugs, the experimental group was much more obvious than the positive controlgroup.It told us that NTT-granule could promote the rehabilitation of limbfunction on rats ,improve the symptoms of neurological deficits and reduceinfarct,by promoting axon growth and branch formation of hypoxic-ischemicin rats brain tissue and the promotion of vascular endothelial regenerationand the formation of new blood vessels.Key words：NaoTaiTong-granule; cerebral ischemic stroke; the blendingof phlegm and blood stasis; Slit2; VEGFAuthor: Huan ZhaoTutor: Jun Li陕西中医学院学位论文独创性声明及使用授权声明学位论文独创性声明本人郑重声明：所呈交的学位论文，是个人在导师的指导下，独立进行研究工作所取得的成果，无抄袭及编造行为。除文中已经特别加以注明引用的内容外，本论文不含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明并致谢。本人完全意识到本声明的法律结果并由本人所承担的法律责任。学位论文作者签名＿＿＿＿＿日期：年月日关于学位论文使用授权的声明陕西中医学院有权保留使用本人学位论文，同意学院按规定向国家有关部门机构送交论文的复印件和电子版，允许被查阅和借阅。本人授权陕西中医学院可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或其他复印手段保存和汇编本学位论文。可以公布（包括刊登）论文的全部或部分内容。（必威体育官网网址论文在解密后应遵守此规定）论文作者签名＿＿＿＿＿日期：论文导师签名＿＿＿＿＿日期：年年月月日日脑泰通颗粒对缺血性脑卒中模型大鼠Slit2及VEGF影响的实验研究引言脑血管病是目前导致人类死亡的三大主要疾病之一。脑卒中是指由于急性脑循环障碍所致的局限性或全面性脑功能缺损综合征或称急性脑血管病事件。脑卒中可分为缺血性脑卒中（Cerebral ischemic stroke）与出血性脑卒中，其中缺血性脑卒中较为常见，又称为脑梗死，约占全部脑血管病的 70%。脑卒中病人