心肌病的分类（英文）课件幻灯.ppt

Genetic Background of the Host Influences the Phenotype of Cardiomyopathies HLA and HCM HLA-DRW4 antigen linkage in patients with hypertrophic obstructive cardiomyopathy Matsumori A et al. Am Heart J. 1981;101:14-16. HLA in hypertrophic cardiomyopathy and rheumatic heart disease Matsumori A et al. Jpn Circ J 1979;43:445-449 HL-A and Hypertrophic Cardiomyopathy Matsumori A et al. Am Heart J 1979;97:428-431 Etiology of HCM Etiology of DCM Etiology of ARVC/D Frequencies of DPB1 Alleles in Patients With HCV-Associated Cardiomyopathy and Controls Both DPB1*0401 and DPB*0901 was significantly associated with HCV-HCM (* P?0.05), whereas none of DPB1 allele demonstrated significant association with HCV-DCM Shichi D, Matsumori A, et al. Int J Immunogenet 2008;35:37-43 DPB1 allele HCV-HCM (2n=76) HCV-DCM (2n=42) Control (2n=264) *0201 0.145 0.143 0.205 *0301 0.053 0.095 0.057 *0401 0.079* 0.024 0.023 *0501 0.368 0.381 0.413 *0601 0.013 – 　　　　　　 0.004 *0901 0.184* 0.119 0.095 Association with Polymorphic of DP?-Chain in HCV-HCM Shichi D, Matsumori A, et al. Int J Immunogenet 2008;35:37-43 Position Amino acid residue Cases (n=38) + - DP? 8 DP? 9 DP? 11 DP? 36 DP? 55 DP? 57 DP? 76 Leu Phe Gly Ala Ala Glu Met Controls (n=132) + - OR (95% CI) P Pc 6 6 6 31 31 6 6 129 129 129 7 7 129 129 3 3 3 125 125 3 3 32 32 32 7 7 32 32 0.12 (0.03-0.52) 0.12 (0.03-0.52) 0.12 (0.03-0.52) 4.03 (1.32-12.35) 4.03 (1.32-12.35) 0.12 (0.03-0.52) 0.12 (0.03-0.52) 0.004 0.004 0.004 0.017 0.017 0.004 0.004 0.008 0.012 0.008 0.034 0.051 0.008 0.012 (Pockets) (6) (9) (6) (9) (9) (-) (4) The polymorphic residues from DPB1 alleles located in P9 pockets (at position 36A and 55A) showed positive associations with HCV-HCM. In contrast, five polymorphic residues showed