g 2407 4口腔喷雾剂的研究-study on g 2407 4 oral spray.docx

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g 2407 4口腔喷雾剂的研究-study on g 2407 4 oral spray.docx

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g 2407 4口腔喷雾剂的研究-study on g 2407 4 oral spray

（必威体育官网网址学位论文在解密后适用本声明）论文作者签字：签字日期：年月日指导教师签字：签字日期：年月日目录中文摘要······································································1 英文摘要······································································4 前言··········································································7 第一章 G-2407-4 口腔喷雾剂的处方前研究 ·······································9 一、仪器与试药·······························································9 1. 实验仪器··································································92. 药品与试剂································································9 二、方法与结果································································9 1. 制剂规格的确定····························································92. 紫外分析方法的建立························································92.1 检测波长的选择···························································92.2 标准曲线和线性范围·······················································102.3 日内日间精密度··························································112.4 重复性··································································113. 溶解度的测定·····························································114. 给药装置的选择及质量考察·················································114.1 给药装置的选择··························································114.2 喷雾泵的质量考察························································114.2.1 室温下喷雾泵的每喷剂量考察············································124.2.2 40℃，RH75%条件下喷雾泵的每喷剂量考察 124.2.3 25℃，RH92.5%条件下喷雾泵每喷剂量的考察 134.2.4 40℃，RH75%条件下喷雾泵的密闭性考察 134.2.5 25℃，RH92.5%条件下喷雾泵的密闭性考察 144.2.6 喷雾泵的装量考察······················································144.2.7 喷雾泵的每瓶总喷次考察················································15三、结论·····································································15四、讨论·····································································16 第二章 G-2407-4 口腔喷雾剂的处方优化·········································17 一、仪器与试药·······························································171. 实验仪器·······························