gal审审3及runx2在脑膜瘤中的表达及意义-expression and significance of gal trial 3 and run x2 in meningioma.docx

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2018-06-04 发布于上海
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gal审审3及runx2在脑膜瘤中的表达及意义-expression and significance of gal trial 3 and run x2 in meningioma.docx

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gal审审3及runx2在脑膜瘤中的表达及意义-expression and significance of gal trial 3 and run x2 in meningioma

Theexpressionand significanceofGal-3andRunx2inMeningioma英文摘要AbstractObjective: ①BytestingtheexpressionofGalectin-3andRuntRelatedtranscriptionfactor-2（Runx2）inmeningiomatissueofdifferentlevelsandsubtypes,theauthortrytoprobeintotheirrelationwithmeningiomapathogenesis.②WiththeknowledgeofmechanismofactionofGal-3andRunx2inmeningioma,theauthortrytofurtheranalyzeanddiscussnewwaysofmeningiomatherapyanditsprognosticevaluation.Method: ①89casesofmeningiomaspecimensconfirmedbyoperationresectionandpathologyintheNeurosurgeryDepartmentoftheaffiliatedhospitalofLuZhouMedicalCollegefrom2009to2011werechoosed,allpatientsofwhichbeforesurgicaloperationhadn’tacceptanyradiotherapyorchemotherapyandhadnoneoplasticdiseasesinotherpartsofbody.Another25casesofnormalmeninxtissuewerechoosedascomparison,patientsofwhichwereallfromthosewhohadacceptedinternalandexternaldecompressionforheadtraumabefore. ②HavingHEstainingforallspecimens,immunohistochemicaltechniquewillbeadoptedwhennecessaryandthenclassifythemeningioma.③Immunohistochemicalstainingwillbeusedtotestthetargetindicatorinthemeningiomatissueandnormalmeninges,includingGal-3、Runx-2andRunx-3。④Withtheguidanceofteacherfromthepathologydepartment,theauthorandhispartnerhavemasteredrecognizingpathologicalsectionwiththemicroscope，thereforetheywillobserveandrecordtheexpressionsituationofthethreeindexesinthemeningiomatissueandnormalmeninx,inclucingeachindex’scolorofpositiveexpressionanditspositioninthetissue.Meanwhile,positiveindexeswillbeclassified(Detailedstandards canbeseeninthefollowingexperimentalresultsandjudgmentstandard).⑤Basedonthetheexperimentalresultsofdataonthethreeindexesclassifiedandhandledbyitslevelandsubtypes,therelationofdifferentindexwithmeningiomawillbeanalyzed.Result:①ThepositiveexpressionrateofGal-3inmeningiomaisverylow,whichismainlyweakpositiveornegativeexpression.whileitspositiverateinnormalmeninxtissuesignificantlyincreases,andthedifferencewasstatisticallysignificant（x2=4.32，P＜0.05）.Wedon’tfindthepositivecorrelationbetweenthepositiv