病理生理学精品课件（复旦大学）02 Hemodynamic Disorders-1.pptVIP

thrombosis LM: platelets trabeculae + neutrophil fibrin + red cells thrombosis Types Mural thrombus Occlusive thrombus Globular thrombus Vegetation 细菌性血栓 肿瘤性血栓 Pale thrombus Mixed thrombus Red thrombus Hyaline thrombus 白色血栓 Pale Thrombus 血小板 纤维蛋白 静脉性/延续性血栓头部 多见于心瓣膜、心腔或主动脉 eg. 赘生物 （Vegetation）, 附壁血栓（mural thrombus) 混合血栓 Mixed thrombus 血小板小梁（trabaculaes）和富红细胞区域交替存在 静脉性/延续性血栓体部 thrombosis 红色血栓 Red Thrombus 红细胞 静脉性/延续性血栓尾部 透明血栓 （微血栓）Hyaline thrombus (microthrombus) 纤维蛋白 与弥散性血管内凝血(DIC)有关 thrombosis thrombosis 附壁血栓 Mural thrombus 赘生物 Vegetation 透明血栓 Hyaline Thrombus 闭塞性血栓 occlusive thrombus 球形血栓 globular thrombus thrombosis 肿瘤性血栓 tumor thrombus 细菌性血栓 bacterial thrombus thrombosis thrombosis Difference between thrombus and postmortem clot Thrombus Postmortum clots 干 dry wet and gelatinous “chicken fat” supernatant 糙 rough surface smooth surface 硬 hard soft 脆 fragile gelatinous 层 Lines of Zahn homogenous 紧 firmly attached no attachment 裂 slit due to contraction, fragmentation, generate embolus no slit Thank you for your attention! 血液循环系统障碍Hemodynamic Disorders Ye Liu （刘 晔） Department of Pathology 《心血运动论》 威廉 哈维 An Anatomical Study of the Motion of the Heart and of the Blood in Animals, 1628 Containing Heart, artery, Vein General circulation Pulmonary circulation Functions Deliver oxygen and nutrients Carry away metabolic wastes 健康的循环系统： ? 正常血容量（Normal blood volumn） ? 血液稳态 （Homeostasis） 血液稳态 血管壁完整性 vessel wall integrity 静水压 intravascular pressure 胶渗压 osmolarity 正常凝血 normal hemostasis Edema 水肿 Hyperemia congestion 充血和淤血 Thrombosis Embolism 血栓形成和栓塞 Infarction 梗死 Hemorrhage 出血 Shock 休克 Three Major Causes of morbidity and mortality ? Myocardial infarction 心肌梗死 ? Pulmonary embolism 肺栓塞 ? Cerebral vascular accident 脑血管意外，中风 Circulation Disturbance General (全身性) Some severe situation affecting all over the body: cardiac dysfunction 心功能不全 shock