医学免疫学精品课件（复旦大学）16 肿瘤免疫.pptVIP

Immunotherapy Adoptive cellular therapy Immunotherapy Anti-tumor Antibodies Her-2/Neu, CD20, CD10, CEA, CA-125, GD3 ganglioside McAb Rituximab 美罗华 Cancer Bevacizumab 阿瓦斯汀 Trastuzumab 赫赛汀 Cetuximab 爱必妥 gemtuzumab ozogamicin alemtuzumab Anti-tumor Antibodies Ab treatment alone; Ab coupled with cytotoxic agents. Anti-tumor Antibodies Ab used alone or coupled with cytotoxic agents Humanization of mouse mAbs; Use cocktails of Abs. High specificity of the Ab; Sufficient amount of Ab enriched within tumor; Avoid systemic effects. Check point blocking Ab (Targeting regulatory molecules on T cells) Cancer Ipilimumab 易普利姆玛 (CTLA-4 blocking Ab) Pembrolizumab (PD-1 blocking Ab) Key notes Concepts: TSA, TAA Evasion of immune responses by tumors Immunotherapy to tumors Thank you! DEPARTMENT OF IMMUNOLOGY 2 reasons, 1)only one authorized for sale in china, under the special agreement with Peiking University Medical press. 2) An exceptionally lucid guide to the latest immunology concepts. Immunology is not an easy concept to digest at first, but luckily this book explains the difficult topics quite well. * 2 reasons, 1)only one authorized for sale in china, under the special agreement with Peiking University Medical press. 2) An exceptionally lucid guide to the latest immunology concepts. Immunology is not an easy concept to digest at first, but luckily this book explains the difficult topics quite well. 2 reasons, 1)only one authorized for sale in china, under the special agreement with Peiking University Medical press. 2) An exceptionally lucid guide to the latest immunology concepts. Immunology is not an easy concept to digest at first, but luckily this book explains the difficult topics quite well. 上图：前列腺癌治疗性疫苗Provenge作用机制 2010年5月1日，美国FDA批准了第一个治疗性疫苗---Provenge，用于治疗前列腺癌，预示着生物治疗向临床转化跨出了一大步，具有里程碑的意义。 * * * * * * * Engagement of inhibitory NK cell receptors such as KIR and CD94/NKG2 by class I MHC molecules delivers an inhibitory signal that counteracts