肺表面活性物质联合鼻塞式持续气道正压通气治疗新生儿胎粪吸入综合征的临床意义[权威资料].docVIP

肺表面活性物质联合鼻塞式持续气道正压通气治疗新生儿胎粪吸入综合征的临床意义 　　[摘要] 目的 研究肺表面活性物质（PS）联合鼻塞式持续气道正压通气（n-CPAP）治疗新生儿胎粪吸入综合征的临床意义。 方法 收集我院新生儿科2015年1月～2016年5月收治的79例新生儿胎粪吸入综合征患儿，根据是否使用肺表面活性物质分为观察组（38例）及对照组（41例），对比两组治疗前与治疗后6 h、12 h、24 h PO2/FiO2和a/APO2比值、n-CPAP使用时间、用氧时间、平均住院天数、改为有创呼吸支持例数等临床指标。 结果 观察组治疗后6 h、12 h、24 h PO2/FiO2、a/APO2比值较对照组明显改善，差异有统计学意义（P0.05）；n-CPAP使用时间、用氧时间、平均住院天数较对照组缩短，差异有统计学意义（P0.05）；观察组改为有创呼吸支持例数较对照组少，差异有统计学意义（P0.05）。 结论 PS联合n-CPAP治疗新生儿胎粪吸入综合征疗效确切，操作简便，适宜临床推广应用。 　　[关键词] 肺表面活性物质；鼻塞式持续气道正压通气；新生儿；胎粪吸入综合征 　　[] R722.1 [] B [] 1673-9701（2016）25-0048-03 　　Clinical significance of pulmonary surfactant combined with nasal continuous positive airway pressure in the treatment of neonatal aspiration of meconium 　　YU Yang 　　Department of Neonatology， Anshun Women and Childrens Hospital in Guizhou Province， Anshun 561000， China 　　[Abstract] Objective To study the clinical significance of pulmonary surfactant combined with nasal continuous positive airway pressure（n-CPAP） in the treatment of neonatal aspiration of meconium. Methods 79 children patients with neonatal aspiration of meconium who were admitted to the Department of Neonatology in our hospital from January 2015 to May 2016 were selected. According to whether pulmonary surfactant was used or not， the patients were assigned to the observation group （38 patients） and the control group （41 patients）. Clinical indicators of PO2/FiO2 and a/APO2 ratios， n-CPAP application time， oxygen time， average length of stay， number of cases of changing to invasive respiratory support before the treatment， 6 hours， 12 hours， and 24 hours after the treatment were compared between the two groups. Results PO2/FiO2 and a/APO2 ratios 6 hours， 12 hours， and 24 hours after the treatment were significantly improved compared with those in the control group， and the differences were statistically significant （P0.05）； n-CPAP application time， oxygen time and average length of stay were shorter than those in the control group， and t