精品口腔粘膜溃疡类疾病课件_3.ppt

NEXT;Introduction;I. Introduction;ulcer;;Recurrent Aphthous Ulcer;? Typing Lehner’s classification minor aphthous ulcer （MiAU） major aphthous ulcer （MjAU） herpetiform ulcer （HU） ? Characteristic recidivity self-healing periodicity;2. Etiology unknown ? immunity : cellular immunity, humoral immunity, complement, autoantibody ? heritage ? infection ：HSV ? environment: psychology;? denutrition ：iron, copper, zinc, folic acid, Vit B12 ? hyperoxide dismutase ? microcirculation disturbance ：lip, nail, apex linguae ? systemic factor ：ulceration of stomach、hepatitis、colonitis、diarrhoea;3. Clinical features minor aphthous ulcer major aphthous ulcer herpetiform ulcer;NEXT;Minor aphthous ulcers;NEXT;NEXT;Major aphthous ulcers ;NEXT;NEXT;Herpetiform ulcers ;disease-process;5. Diagnosis;6. Differential diagnosis;;7. Treatment;Topical application of a steroid ointment reduces discomfort and decreases the duration of the lesions. Topical anesthetics, antibiotics, mouthwashes, etc., have been used. In severe cases, intralesional steroid injection or systemic steroids in a low dose (10-20 mg prednisone) for 5-10 days reduce the pain dramatically. ;III. Beh?et’s disease;3. Clinical features 1) oral mucosa: minor aphthous ulcer 2) genital lesion: ulcer 3) skin lesions: erythema nodosum, epifolliculitis, pustule after needling 4) ocular lesions: conjunctivitis, recurrent iritis 5) others systems: joint, digestive, cardiovascular, nervous, respiratory, urinary;Beh?et’s disease;4. Pathology ： Histopathologic changes consist of a perivascular mononuclear cellular infiltrate, endothelial cell swelling or necrosis, partial luminal obliteration and occasional fibrinoid necrosis of the vessels. ;5. Diagnosis 1) recurrent oral ulceration 2) recurrent genital ulceration 3) eye lesions 4) skin lesions 5) positive pathergy