骨质疏松的防治阿法迪三课件.ppt

* Risedronate is also available in low and high, daily or weekly doses as shown here. Administration guidelines are the same as for alendronate and include: Take risedronate on an empty stomach, first thing in the morning, with 8 ounces of tap water (no other liquid). Wait at least 30 minutes before eating or drinking and remain upright for at least 30 minutes after taking this medications. Side effects are uncommon and include upper gastrointestinal disorders including dysphagia, esophagitis and esophageal or gastric ulcer.1-2 1 Reginster J, Minne HW, Sorensen OH, Hooper M, Roux C, Brandi ML, Lund B, Ethgen D, Pack S, Roumagnac I, Eastell R. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group.Osteoporos Int. 2000;11(1):83-91. 2 Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut CH 3rd, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA. 1999 Oct 13;282(14):1344-52. * Calcitonin is another antiresorptive agent that can be used in osteoporosis treatment. Administration is as a nasal spray or injectable. * 让我们来看一下著名的PROOF试验结果。蓝色代表密盖息，黄色代表安慰剂。在安慰剂组203例患者中，发生椎体骨折的百分比为29.6％，而在200IU密盖息治疗组患者中，发生椎体骨折的百分比仅为19.3％。研究数据显示，对于既往曾发生过1－5次椎体骨折的患者，密盖息能够显著降低患者骨折危险性达36％。 Ref.2 * Side effects associated with nasally administered salmon calcitonin were found to be mild and of low incidence. Long-term administration of calcitonin in humans is associated with no serious or long-term side effects. Nasal spray calcitonin may cause nasal irritation and bloody or runny nose, as well as backache and headaches. Injected calcitonin may cause allergic responses, such as itching or redness and swelling at the inj