Biomarkers for psychosis National eScience Centre精神病国家电子科学中心生物标志物.pptVIP

NeuroGrid PsyGrid(and maybe even NeuroPsyGrid) Stephen Lawrie Alan Williams Edinburgh Manchester The main issues in (UK) clinical brain imaging studies Potential: - demonstrate effects of risk factors, including genes; early diagnosis; treatment response / prognosis prediction; treatment effect monitoring; biomarker for novel drug development Concerns: lack of standardisation across scanners and even in basic approach to e.g. ‘connectivity’; lack of normative data reference points for relevant age ranges; safe data storage; expense; constantly developing technology Neurogrid – psychosis exemplar Database and ontology, building on EHRS data set (0.5WTE) Scanner harmonisation issues, focussing on EHRS use of two machines (1WTE) Combined analysis of psychosis data sets from Oxford Edinburgh, focussing on sex / assymmetry (1 WTE) Registration and Partial Volume Metric for Multi-Center sMRI Scanner Harmonization Moorhead TWJ, Job DE, Gountouna V-E, Johnstone EC, Lawrie SM. HBM2005. NeuroImage 2005 Signal-to-Noise (SNR) and Contrast-to-Noise (CNR) metrics in longitudinal and multicenter MRI studies Gountouna VE, Moorhead TWJ, Job DE, Johnstone EC, Lawrie SM. HBM2005 NeuroImage 2005 Entropy as a measure of scanner and sequences change. Dominic E. Job, T. William J. Moorhead, Eve C. Johnstone, Stephen M. Lawrie. NeuroImage 2006 Volume 31, Supplement 1 Annual Meeting Human Brain Mapping, June 11-15 Florence Italy Test-retest reliability of the Hayling sentence completion task: assessment for multicenter fMRI using voxel-wise Intraclass Correlation Coefficients (ICCs). Viktoria-Eleni Gountouna, Heather Whalley, T.William Moorhead, Dominic Job, David McGonigle, Eve Johnstone, Stephen Lawrie. HBM2006 NeuroImage 2006 Volume 31, Edinburgh High Risk Study Baseline measures genetic liability dermatoglyphics obstetric complications minor physical anomalies / neurological ‘soft signs’ CBCL SIS RISC Also took blood for genes at the end of the study Repeated mea