外文翻译激光组织接合激光束光斑尺寸和研究概况.docxVIP

附录A 英文原文Laser Tissue Welding: Laser Spot Size and Beam Pro?le StudiesAbstract：This paper evaluates the effect of laser spot diameter and beam pro?le on the shape of the thermal denaturation zone produced during laser tissue welding. 2-cm-long full-thickness incisions were made on the epilated backs of guinea pigs in vivo. India ink was used as an absorber and clamps were used to appose the incision edges. Welding was performed using continuous-wave 1.06-m, Nd:YAG laser radiation scanned over the incisions to produce 100-ms pulses. Laser spot diameters of 1, 2, 4, and 6 mm were studied, with powers of 1, 4, 16, and 36 W, respectively. The irradiance remained constant at 127 Monte Carlo simulations were also conducted to examine .the effect of laser spot size and beam pro?le on the distribution of photons absorbed in the tissue. The laser spot diameter was varied from 1 to 6 mm. Gaussian, ?at-top, dual Gaussian, and dual ?at-top beam pro?les were studied. The experimental results showed that 1-, 2-, 4-, and 6-mm-diameter spots produced thermal denaturation to an average depth of 570, 970, 1470, and 1900 m, respectively. Monte Carlo simulations demonstrated that the most uniform distribution of photon absorption is achieved using large diameter dual ?at-top beams. Index Terms— Denaturation, laser biomedical applications, laser materials-processing applications, laser welding, Monte Carlo methods, optical propagation.MATERIALS AND METHODSExperimentsIn vivo welding of skin incisions was performed at constant irradiance to investigate the effect of various laser spot sizes (1-, 2-, 4-, and 6-mm-diameter FWHM) on the extent of thermal denaturation at the weld site. Adult female albino guinea pigs (Hartley, age 7–8 weeks, weight 400–500 grams) were shaved then epilated with a chemical depilator (Nair,Carter-Wallace, Inc., New York, NY). Each guinea pig was anesthetized with atropine (0.05 mg/kg), ketamine (30 mg/kg), and xylazine (2 mg/kg) administered by intraperitoneal in