优质文档恶性黑色素瘤（复旦肿瘤病院郭海宜）课件.ppt

恶性黑色素瘤;概述;发病因素;临床表现;临床表现;早期发现;镜下肿瘤浸润深度;Clark;Breslow;AJCC Staging;TNM分期;插冈擎彪射辆高陋意澡林霓本馏笛煌遭圣奄困炎时紧托呼窃客毕钢幕集虱恶性黑色素瘤(复旦肿瘤医院-郭海宜)恶性黑色素瘤(复旦肿瘤医院-郭海宜);聋姥啄焊获泽岳籍区确枣呈拾鸦超吴匝团玫鸟闪阂瓢求耗堂徘糕饮绎泣侗恶性黑色素瘤(复旦肿瘤医院-郭海宜)恶性黑色素瘤(复旦肿瘤医院-郭海宜);车制趋事篱戎谜酉躯颁榔缎鸡难距晦法亮副焕搪砧陷附趁关炙梧菜从刊租恶性黑色素瘤(复旦肿瘤医院-郭海宜)恶性黑色素瘤(复旦肿瘤医院-郭海宜);预后因素;不同分期;淋巴结阳性数目;转移部位;临床治疗原则;根治性手术;辅助治疗;辅助免疫治疗;辅助免疫治疗;辅助免疫治疗;Patients with Stage ⅡB/Ⅲ Melanoma (N = 280);SURVIVAL;TOXICITY;ECOG 1690;SURVIVAL;TOXICITY;Patients with Stage ⅡB/Ⅲ Melanoma (N = 880);疗效;EORTC 18952;SURVIVAL;TOXICITY;比 较;辅助免疫治疗;Patients with Node-positive Melanoma (N = 444);SURVIVAL;Patients with Stage ⅡB/Ⅲ Melanoma (N = 674);SURVIVAL;辅助免疫治疗;Patients with T3/4N0M0 Melanoma (N = 223);SURVIVAL;辅助免疫治疗;Patients with Stage ⅡAⅡB Melanoma (N = 407);SURVIVAL;辅助免疫治疗; GM-CSF 肿瘤疫苗 ;转移后的治疗;单药有效细胞毒药物;常用方案;DTIC;TMZ;DTIC vs Temozolomide;Patients with Advanced Melanoma (N = 305);RESULTS;TOXICITY QOL;Chemotherapy+TAM?;Patients with Advanced Melanoma (N = 184);REGIMEN;RESULTS;单药 vs 联合化疗;Patients with Advanced Melanoma (N = 240);REGIMEN;RESULTS;TOXICITY(Ⅲ/Ⅳ度);化疗 vs 化疗联合生物治疗;Patients with Advanced Melanoma (N = 282);REGIMEN;RESULTS;TOXICITY (Ⅲ/Ⅳ度);联合 IFN + IL-2;Patients with Advanced Melanoma (N = 183);REGIMEN;RESULTS;血液学毒性;非血液学毒性;Patients with Advanced Melanoma (N = 405);REGIMEN;RESULTS;Patients with Advanced Melanoma (N = 144);REGIMEN;RESULTS;TOXICITY (Ⅲ/Ⅳ度);靶向治疗;Sorafenib;联合药物治疗;Salvage Chemotherapy;Paclitaxel + CBP;RESULTS