2014嗜酸性食管炎课件.ppt

结论 在该研究中，Cytosponge准确、安全且耐受性良好 获得的样本远多于细胞学方法，且接近于活检，但在嗜酸性细胞计数方面存在限制?? 需要更大型的研究来更好地确立更精确的诊断节点，并证明持续的安全性和疗效 Anupama?Ravi, et al. Cytosponge?Evaluation?of?Eosinophilic?Esophagitis?in?Comparison?to?Endoscopy:? Accuracy,?Safety,?and?Tolerability, p18 EoE新治疗靶点 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p5 EoE中Desmoglein-1减少 假设- desmoglein-1下调导致EoE中食管上皮病理特征 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p10 Desmoglein-1减少改变屏障结构 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p11-12 屏障功能障碍可能与EoE病理机制有关结构 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p13 屏障功能损伤 抗原 过敏性炎症c 致病周期 Th2细胞因子 (IL-13) 胸腺基质淋巴细胞生成素 (TSLP) TSLP的作用 类似于IL-7 促进B细胞和DC激活 促进Th2激活 假设- TSLP和嗜碱性细胞可导致食管炎/食管功能障碍 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p16 TSLP可诱发小鼠食管炎症 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p19 嗜碱性细胞可导致食管嗜酸性细胞增多 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p20 TSLP/嗜碱性细胞与嗜酸性细胞增多有关 以TSLP或嗜碱性细胞轴为靶点可阻断食管嗜酸性细胞增多 Glenn T. Furuta, et al. Novel Therapeutic Targets in Eosinophilic Esophagitis: p21 感 谢 关 注 * Furuta G et al. Gastroenterology 2007;133:1342-63. Liacouras C et al. J Allergy Clin Immunol 2011;128:3-20. * Almansa C et al. Am J Gastroenterol 2009;104:828-33. * Rodrigo S. Am J Gastro 2007 * Genevay M et al. Arch Pathol Lab Med 2010 * Odze RD. Am J Gastroenterology 2009 * Molina-Infante J, et al. Clin Gastro and Hepatology 2011 * Dellon ES et al. Clin Gastro and Hep 2009 * Dellon, Am J Gastro, 2013 * Blanchard, J Clin Invest, 2006; Mueller, Histopath, 2008; Rothenberg, Gastro, 2009; Dellon, AJG, 2012 Straumann, JACI, 2001; Gupta et al, JPGN, 2006; Kirsch et al, JPGN, 2007; Lucendo, Am J Surg Path, 2007; Dellon, AJG, 2011 * Arias et al. Gastroenterology 2014; Epress. * Gonsalves N.Gastroenterology 2012; 142:1451-9.e1 Lucendo AJ. J Allergy Clin Immu