激素在溃疡性结肠炎的应用ppt课件.ppt

mild and moderate type with largely lesion For mild and moderate patient, First choice oral Sulfasalazine ，while it is not effective，recommend oral prednisone 20～60 mg/d mild and moderate type with Distal lesion Corticosteroids topical therapies Effect of topical administration of budesonide and tranditional corticosteroids on active distal ulcerative colitis or proctitis Shang hai Jiao tong University School of Medicine Research from Conclusion The effects of budesonide and traditional corticosteroids on active distal Ulcerative colitis or Proctitis are similar. However, budesonide maybe Preferable to traditional corticosteroids ,since its inhibitory effect on Plasma cortisol level is lower than traditional corticosteroids. adverse effects Such as cushingoid features, emotional and psychiatric disturbances, infections, glaucoma. Complications include gastroduodenal mucosal injury, impaired wound healing, and metabolic bone disease. steroid-dependency Although short term control of symptoms can be achieved with steroid treatment, followed by recurrence during alleviating dose or stopping administration． this pattern of drug response，known as steroid-dependency． The therapeutic plan for steroid-dependency Azathioprine 2-2.5mg/kg*d Cyclosporin therapy for severe ulcerative colitis Infliximab ——could not only maintain the clinical remission in UC patients，but also decrease the colon resection rate for patients with moderate to severe refractory UC Else therapies intestinal stem cells antibiotics If failure of medical therapy ，the Surgical therapy should be taken. The end The Clinical Application of Corticosteroids in Ulcerative Colitis rui nan Wang Two parts The introduction of Ulcerative colitis The clinical application of Corticosteroids in Ulcerative colitis Ulcerative colitis Definition: Chronic non-specific colitis Inflammation of the mucosa and submucosa of the large intestine Features: diarrhe