炎症性肠病面临的问题与挑战ppt课件.ppt

* * In Japan, where the Ministry of Health, Labor and Welfare maintains a national IBD registry, the cumulative number of UC and CD patients has risen three times since the early 1990s, the total number being now greater than 100,000 (Fig. 1). CD is less common than UC, although its prev- alence is also increasing [4] * n a recent update on the descriptive epidemiology of IBD in Korea by Yang et al., (23) relying on population-based data from an urban district in Seoul, the adjusted incidence rates of Crohn’s disease and UC were 0.53 cases per 105 person- years (95% CI, 0.44 to 0.62) and 1.51 cases per 105 person- years (95% CI, 1.34 to 1.67), respectively, in 1986–2005. Comparing the period 1986–1990 with 2001–2005, the mean annual incidence of Crohn’s disease had increased from 0.05 cases per 105 person-years to 1.34 cases per 105 person-years, while the UC incidence rates had climbed from 0.34 cases per105 person-years to 3.08 cases per 105 person-years. Yang and colleagues also found the ratio of UC incidence to Crohn’s incidence decreasing in Korea, indicating that the incidence trend of Crohn’s disease was accelerated compared to UC, a phenomenon observed in many Western countries as well (35, 36). I * 121 UC patients 80 CD patients There was an impressive increase in the number of new cases diagnosed over these 3 year blocks. * Increase in annual incidence in the Prince of Wales Hospital catchment area. Increase in both CD and UC – therefore not merely RECLASSIFICATION of one form of IBD into the other * * * * * * * * * * * * TNFSF15 is an ethnic-specific IBD gene (Picornell et al. IBD 2007) * * * Behaviour of disease. * * HLA-B27 was not routinely tested. 1. AS/ SI: CD 7 patients; UC 3 patients 2. Eye: CD 3 patients (2 anterior uveitis, 1 episcleritis); UC 2 patients (2 anterior uveitis) 3. Skin: CD 2 patients (1 pyoderma, 1 erythema nodosum); UC 3 (3 EN) 4. PSC confirmed by ERCP: UC 2 patients (1 of whom developed COLONIC carcinoma – a known compli