糖尿病自身抗体临床意义ppt课件.pptVIP

* Insulin was the 1st autoantigen to be defined in type 1 DM patients. Insulin is a dimeric protein with a 21 amino acid A chain, and a 30 amino acid B chain joined by two disulphide bonds. The physiological functions of this 6kD protein are well known, and include glucose uptake into the cell, glycolysis, glycogenesis, adipogenesis, and gluconeogenesis. Insulin was the 1st peptide hormone sequenced and defined by crystallography, and was used for the 1st licensed medication engineered genetically. * * * KB Mai 2010; Quelle： Eisenbarth, 2008, Natural History of Type 1 Diabetes Znt8 is charact