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Weebly百日咳 课件
BORDETELLA K.V.PRAVEEN CHANDER Important species Bordetella pertussis - Bordet-Gengou bacillus Bordetella parapertussis Bordetlla bronchiseptica - ancestral form Bordetella avium -causes respiratory disease in turkeys Virulence Steele, R.W. Pertussis: Is Eradication Achievable. Pediatric Annals. Aug 2004. 33(8):525-534 Adhesions Filamentous hemagglutinin Pertactin Fimbriae http://www.rivm.nl/infectieziektenbulletin/bul1306/kinkhoest.jpg http://www.my-pharm.ac.jp/~yishibas/research/Pertussis1.jpg Toxins Pertussis Toxin Adenylate Cyclase Toxin Tracheal cytotoxin Dermonecrotic toxin Heat-labile toxin www.ibl.fr/u447/u447.htm Pertactin Outer membrane protein antigen present in all virulent strains Included in acellular pertussis vaccine Bordetella parapertussis Infrequent, cause of whooping cough Disease is mild Pertussis vaccine do not give protection Bordetella bronchiseptica Peritrichate flagella Antigenetically related to pertussis and abortus Occurs naturally in the respiratory tract of several sps of animals THANK YOU * B. pertussis invades the human host through the inhalation of respiratory droplets and adheres to the ciliated epithelium of the respiratory tract (Babu et al., 2001). It was believed that B. pertussis was an entirely extracellular pathogen, but it has recently been shown that B. pertussis can invade aveolar macrophages. This pathogen can multiply rapidly on the mucosal membrane of the upper respiratory tract, producing adhesions that allow it to colonize by adhering to the ciliated epithelium (Babu et al., 2001). B. pertussis must survive within the hostile environment of its human host by producing a variety of virulence factors in an attempt to evade or counter the immune system of the host as it tries to clear the infection (Barnes et al., 2001). These virulence factors include adhesions such as filamentous hemagglutinin, agglutinogens, peractin, and fimbriae as well as a number of toxins including pertussis to
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