Fasciitis Santa Monica College坏死性筋膜炎圣莫尼卡学院课件.ppt

Necrotizing Fasciitis Justina Du, Thao Nguyen, Camille Thorsen What is Necrotizing Fasciitis? life-threatening, progressive, rapidly spreading, inflammatory infection located in the deep fascia. infection rapidly destroy the skin and soft tissue beneath it Also known as: “flesh-eating” bacteria. Other names: β-hemolytic streptococcal gangrene, Meleney ulcer, acute dermal gangrene, hospital gangrene, and necrotizing cellulitis. 3 types of NF. Type I : a polymicrobial flora. Type II Group A β-Streptococcus bacteria (most common case) Type III : marine vibrio gram-negative rods. How does one contract NF? exposed to an individual with an opening in their skin. direct contact with someone carrying the bacteria the bacterium being carried by the person itself. sight of entrance can be as minor as a paper cut or a pin prick. enter through weakened skin, as a contusion, a bruise, a blister, or even an abrasion. Can happen to anyone!!!!!! Cofactors that Increase risks Diabetes Alcoholism Immuno-suppression Severe illnesses: heart, lung, or liver disease Obesity What’s going on inside your body? Bacteria eat away at tissue between skin and muscle Increase in sensitivity or anaesthetic feel to the skin itself Inflammatory response by immune system Bacterial toxins released Cytokines impede function of phagocytic cells Anaerobes thrive speeding up necrotic process Endothelial cells become damaged; Increased permeability of the lining of vessels in the body Poor blood supply inhibit: Inflammatory response process Ability for the immune system to properly work Ability to transfer antibiotics to the affected fascial layer Vasoconstriction and thrombosis ? edema ? hypoxia ? necrosis of the fascia, skin, soft tissue, and muscles. Additional necrosis involving the subcutaneous nerves. What are the early symptoms and signs of NF? Flu like symptoms that include fever, chills, nausea, weakness, dizziness, aches and a heat rate of more than 100 beats per minute.