分子免疫学T细胞免疫应答机制 204硕士.ppt

Activation and functions of macrophages in CMI Th2-Mediated Immune Responses The physiological role of Th2 cells Elimination of helminthic infection Pathological roles of Th2 cell The underlying cause of allergic reactions Effector functions of Th2 cells Promotion of antigen-specific IgE production Activation of eosinophils and mast cells Alternative macrophage activation Barrier immunity by Th2 cytokine Effector functions of Th2 cells The effector function of Th2 cytokines IL-4 and IL-13 Stimulate the production of antigen-specific IgE Alternatively activate macrophages IL-4 promotes expulsion of microbes while IL-13 stimulates mucus secretion IL-5 Recruit and activate eosinophils The orchestration of macrophage activation and polarization by Th cells Biswas S, et al. Nature Immunol, 2010 The physiological role of Th17 cells Protection against extracellular bacterial and fungal infections Pathological roles of Th17 cell may be important in meditating tissue damage in immune-mediated inflammatory diseases, e.g. autoimmune diseases Th17-Mediated Immune Responses Th17-specific cytokines IL-17A IL-17F IL-22 Effects of Interleukin-17 on Cell Functions and Its Role in the Pathophysiology of Diseases. IL-22 Proinflammatory and protective properties Proinflammatory role in psoriasis, RA and some infection Protective role in IBD, infection, and liver injury OConnor Jr et al. Nature Immunol 2010 A simplified model for pleiotropic TH17 cytokines in coordinating inflammation protection Chronic inflammation Bettelli E, T Korn, M Oukka, and VK Kuchroo. Induction and effector functions of TH17 cells. Nature 453:1051-1057, 2008 Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nature Reviews Immunology 8:337-348, 2008. Farrar JD, H Asnagli, and KM Murphy. T helper subset development: roles of instruction, selection, and transcription.