Neurobiology of Alcoholism Insights from the Dark Side of 酒精中毒的见解从黑暗的神经生物学课件.pptVIP

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Neurobiology of Alcoholism Insights from the Dark Side of 酒精中毒的见解从黑暗的神经生物学课件.ppt

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Neurobiology of Alcoholism Insights from the Dark Side of 酒精中毒的见解从黑暗的神经生物学课件

* KoobG/CNAD/dia1/063008jh * * KoobG/CNAD/gra2/031809jh Text in PPT * KoobG/NP/dia4/053102jh * * KoobG/NP/wor1/070902jh * KoobGCNADdia2c090808jhRED * KoobG/MIND/gra9/013106jh * KoobG/NP/wor2/030104jh * KoobG/NP/wor1/030104jh * KoobG/NP/gra17/112801jh * KoobG/NP/gra1/061103jh * no# ppt: volkow d2 activity * KoobG/MIND/gra9/013106jh * KoobG/NP/wor2/030104jh * KoobG/NP/dia2/011000jh * KoobG/NP/dia1/061499jh * no# ppt: crf agon/antagon text * * KoobG/CNAD/gra1c/020608jh * KoobG/NP/sca1/102903jh * KoobG/NP/gra1/071502jh * KoobG/CNAD/dia1/111507jh * KoobG/NP/gra3/033104jh * KoobG/NP/gra6/120401jh * KoobGNPgra1c031805jh * * KoobG/CNAD/gra1/102708jh * KoobG/CNAD/wor2/021908jh.ppt retyped * 023scan.tif * KoobGCNADdia2c090808jhGREEN * * WeissB/NP/gra2c/060104jh * KoobG/CNAD/dia4/011608jh * * * KoobG/CNAD/dia3/030607jh animated * KoobG/NP/wor2/030104jh * KoobG/CNAD/dia9b/012508jh Competitive CRF Antagonist Injected into the Amygdala Blocks Conditioned Place Aversionto Opiate Withdrawal From: Heinrichs SC, Menzagi F, Schulteis G, Koob GF and Stinus L, Behav Pharmacol, 1995, 6:74-80. Increase in Brain Reward Thresholds during Escalation in Heroin Intake in Rats with Prolonged Access to Heroin (23-hr/day) From: Kenny PJ, Chen SA, Markou A and Koob GF Journal of Neuroscience 26 (2006) 5894-5900 CRF1 Antagonist R121919 Decreases Heroin Self-Administration in Rats with 12 h Extended Access From: Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice K, Lee MJ, Zorrilla EP and Koob GF, Addict Biol, in press. Role of Corticotropin-releasing Factorin Dependence CRF antagonist effects on withdrawal-induced anxiety-like responses Drug Cocaine Opioids Ethanol Nicotine ?9-tetrahydrocannabinol Withdrawal-induced changes in extracellular CRF in CeA ↑ ↑ ↑ ↑ ↑ CRF antagonist effects on dependence-induced increases in self-administration ↓ ↓ ↓ ↓ nt CRF antagonist reversal of stress-induced reinstatement ↓ ↓ ↓ ↓ nt ↓ ↓ ↓ ↓ ↓ * = aversive effects with place conditioning. nt = n