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Plants Used In Cancer Treatment:用于癌症治疗的植物.ppt

Plants Used In Cancer Treatment:用于癌症治疗的植物.ppt

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Plants Used In Cancer Treatment:用于癌症治疗的植物

Plants Used In Cancer Treatment Part - II Mayapple - Podophyllum peltatum Perennial plant in the barberry family (Berberidaceae) Description Distribution Well known poisonous plant Traditional uses of mayapple Rhizomes dried and ground to a powder Powerful purgative Also used as a poultice to treat warts and tumorous growths on the skin Use in cancer chemotherapy Resin from mayapple rhizomes used in cream to treat cancerous tumors, polyps and granulations in traditional medicine Podophyllin (resin from rhizome) was used by physicians in Missouri, Mississippi, and Louisiana by 1897 for treatment of genital warts Active Compounds in Rhizome Podophyllum peltatum rhizome contains high concentrations of anticancer lignans and other cmpds (16 in all) podophyllotoxin a and b peltatin Another species - Podophyllum emodii podophyllotoxin a and b peltatin berberine – an alkaloid which can be used to treat fevers (including malaria) and as an antibiotic Active compound in mayapple In the plant podophyllotoxin exists as a glycoside Active part is the aglycone Mode of action of podophyllotoxin Podophyllotoxin acts as a cell poison for cells undergoing mitosis Too toxic for chemotherapy use Used in creams as treatment for genital warts Genital warts caused by HPV (human papillomavirus) associated with cancers of the genitals (squamous cell carcinomas) Side effects of podophyllotoxin Adverse reactions to topical applications include burning, inflammation When the drug was being investigated as a chemotherapy agent, it caused nausea, vomiting, fever, mouth ulcers, diarrhea, nervous system problems, seizures, kidney damage, etc. Semi-synthetic derivatives Etoposide and teniposide are derivatives of phyllotoxin that are much less toxic and are safely used in chemotherapy Etoposide is much more widely used Both compounds block the cell cycle in at least two specific places Today these are produced from the Podophyllum emodii from SE Asia but supply is dwindling and USDA sci

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