vegf在胃癌患者血清及肿瘤组织中的表达方法.ppt

VEGF在胃癌患者血清及肿瘤组织中的表达及其意义 猫橇朽就民虱走帘面肥隐装未缺拾饿辜璃锦傣鼓肯茧启盐晾锑废城勤膊锌VEGF在胃癌患者血清及肿瘤组织中的表达方式VEGF在胃癌患者血清及肿瘤组织中的表达方式 ［摘要］  目的   研究血管内皮细胞生长因子（VEGF）在胃癌患者血清及肿瘤组织中的表达情况，探讨其临床意义。方法  应用ELISA法对60例非肿瘤疾病手术患者和60例胃癌患者术前、术后血清VEGF水平进行定量测定，并应用免疫组化法测定肿瘤组织的VEGF。结果  胃癌患者术前血清VEGF高于对照组（P＞0.05）。两组术后较术前升高，肿瘤组术后较术前升高（P＜0.05）。肿瘤组术前血清VEGF水平、肿瘤组织中的VEGF与浆膜受累、淋巴结转移及临床病理分期有关。肿瘤组术后随访30～36个月中出现复发转移和死亡的患者，术前VEGF表达较其他患者升高（P＜0.05）。结论  血清VEGF水平及肿瘤组织中的VEGF与胃癌的浸润、转移有关，检测血清VEGF及肿瘤组织中的VEGF对胃癌浸润、转移程度和预后的判断有重要意义。 嚏糟郝沿苫肝刃饮摄奖皖刚代左嘉靴匹显域晌署巳箩易袍置眼求怕蔷决化VEGF在胃癌患者血清及肿瘤组织中的表达方式VEGF在胃癌患者血清及肿瘤组织中的表达方式 ［关键词］  胃肿瘤；微转移；血管内皮生长因子        Expression and significance of VEGF in serum and tumor tissue in gastric cancer        ZHOU Hai-yin，LI Jian，QIAO Shi-ming，et al.Department of General Surgery，The Central Hospital of Yangpu District，Shanghai 200090，China 炉灾炭酬瞅捏惦橙城酷耐根瞒耙壕寸朴志渭业懦稽淬顽喊国呢升贮措颊蔫VEGF在胃癌患者血清及肿瘤组织中的表达方式VEGF在胃癌患者血清及肿瘤组织中的表达方式 ［Abstract］  Objective  To evaluate the clinical significance of vascular endothelial growth factor (VEGF) expression in serum and tumor tissue in gastric cancer patients.Methods  The pre-operational and post-operational levels of serum VEGF were measured by ELISA kit in 60 cases of gastric cancer and 60 cases of non-carcinoma as the control group，the expression of tumor tissue VEGF was measured by immunohistochemical assay.Results  The pre-operational level of serum VEGF in gastric cancer was higher than that in the control group(P＞0.05). 完假殃孰虐毒范宴豆邯嘲庚狱眷法渣搜箍喇晕氖缆量箱得圈计首瓶恬鲤忍VEGF在胃癌患者血清及肿瘤组织中的表达方式VEGF在胃癌患者血清及肿瘤组织中的表达方式 The post-operational level of serum VEGF was increased in both groups，especially in the tumor group(P＜0.05).The expression of VEGF in serum and tumor tissue was positively correlated with tumor invasion depth，lymph-node metastasis and clinical pathological stage.A follow up of 30～36 months reveals the pre-operational level of serum VEGF of tumor recurrence and death in patients was higher than the others in the tumor group(P＜0.05). 翰舌把剑介寝悟浦份薯吗始演唯力策漾撤态疼必桃孝砚檄岁冯扒睦崖魏腔VEGF在胃癌患者血清及肿瘤组织中的表达方式VEGF在胃癌患者血