Systematic Review of Dietary Supplement Efficacy and Saf：膳食补充剂的疗效和安全系统评价.ppt

* * * * * Systematic Review of Dietary Supplement Efficacy and Safety Paul M. Coates, Ph.D. Office of Dietary Supplements National Institutes of Health Department of Health and Human Services AHRQ Annual Meeting September 2008 NIH Funding for Dietary Supplement Research Has Increased Significantly $ Million ODS Mission is to Strengthen Knowledge and Understanding of Dietary Supplements Evaluate Scientific Information Stimulate and Support Research Disseminate Research Results Educate the Public to Foster an Enhanced Quality of Life and Health for U.S. Population Echinacea Echinacea purpurea  Evidence-Based Review Program Congressional Language for FY 2001 ODS Appropriation “The Office is encouraged, in consultation with NCCAM, AHRQ, and FDA to review the current scientific evidence on the safety and efficacy of dietary supplements now on the market, which could then form a basis for further research, education of practitioners and consumers, and whether further regulatory requirements are necessary.” Evidence-Based Review Program Systematic review of the literature, with meta-analysis as appropriate, on DS efficacy and safety In collaboration with the Agency for Healthcare Research and Quality (AHRQ) Evidence-Based Practice Center Network Major reason for conducting these reviews is to assist NIH in the development of research agendas ODS Evidence-Based Review Program Chromium and insulin sensitivity* Ephedra for weight management and athletic performance enhancement* (with NCCAM) Omega-3 fatty acids for cardiovascular disease prevention* (with NHLBI) and other health indications Health effects of soy (with NCCAM) Antioxidant phytochemicals/B vitamins and neurodegenerative diseases*(with NCCAM) Multivitamins/multiminerals and chronic disease prevention (with OMAR) Coagulation, diet, and dietary supplements Health effects of vitamin D (with multiple partners) *Congressional mandate Health Effects of Omega-3 Fatty Acids Asthma