肿瘤周围浸润的pd-l12bcd192bb淋巴细胞在乳腺浸润性导管癌中的作用及其生物学意义.pdf

+ + 肿瘤周围浸润的PD-L1 CD19 B 淋巴细胞在乳腺浸润性导管癌中的作用及其生物学意义 英文摘要 positive rate of PD-L1 expression gradually increased, and the difference was statistically significant (P = 0.0026). Among the 134 cases of invasive breast cancer, expression of PD-L1 was 81.3% (109/134), and it rised with the increase of pathological grade, and the difference was statistically significant (P = 0.0102). (3) With the increase of the degree of malignancy, the density of B lymphocytes infiltrating surrounding the tumor was gradually increased, and the difference was statistically significant (P0.0001), and it rised with the increase of pathological grade. In other words, poorer the tumor cell differentiated, the density of B lymphocytes infiltrated surrounding the tumor was higher, and the difference was statistically significant (P0.0001). (4) With the increase of the degree of malignancy, the expression of PD-L1 on B cells infiltrated surrounding tumor was gradually increased, and the difference was statistically significant (P0.0001).With the increase of pathology grade of tumor, the concentration of B lymphocytes infiltrated surrounding the tumor gradually increased. In other words, poorer the tumor cell differentiated, the concentration of B lymphocytes infiltrated surrounding the tumor was higher, and the difference was statistically significant(P0.0001).(5) With the increase of the degree of malignancy, the expressing of PD-1 on lymphocytes and CD4+ T cells infiltrated surrounding the tumor gradually increased ,and the difference was statistically significant (P0.0001).(6) Among + + the PD-1 CD4 T lymphocytes, the positive rate of PD-L1 was 86.7% (39/45), the negative rate was 13.3% (6/45), and the difference was statistically significant (P0.0001, kappa = 0.059). Conclusion: (1) With the