年产8000万片扑米酮车间的设计.doc

南华大学化学化工学院毕业设计PAGE v PAGE i 年产8000万片扑米酮（100mg/片）车间设计摘要：扑米酮片在体内约有25%氧化为苯巴比妥，另一部分裂解为苯乙基丙二酰。扑米酮及其代谢产物均有抗癫痫活性，主要用于使用其他抗癫痫药无效的癫痫大发作、精神运动性发作，对小发作无效，与苯巴比妥合用能增强疗效。以扑米酮为主要原料，通过粉碎、筛分、混合、制粒、干燥和压片制备扑米酮片。设计制备该制剂的工艺流程，并通过物料衡算及能量衡算，按照实际生产能力选择出各个流程所需的生产设备和型号,并根据生产要求设计一层车间,使其符合GMP要求。该工艺合理，设备简单，车间布局合理，符合设计要求。关键词：扑米酮片；工艺流程；车间设计Annual output of 80 million pieces primidone (100 mg/piece) workshop designAbstractAbout 25% of primidone in the body can be oxidated phenobarbital. The other part can be crackde benzene ethyl propylene amide. Primidone and its metabolites have antiepileptic activity. Mainly are used for other antiepileptic invalid epilepsy big attack, spirit athletic attack.But it is invalid to the little attack. Primidone shares with phenobarbital can enhance the curative effect. Primidone is the main raw material in the drug . The crushing, screening, mixed, granulation, drying and pressing pieces prepare for primidone pieces. Design for the preparation process. Then figure out the material balance calculations and energy balance calculations.According to actual production ability the students can choose the various processes for manufacture and model. Design a layer of workshop to meet the requirement of GMP according to the production requirements. This process is reasonable. The equipment is simple. The workshop layout is reasonable and comply with the design requirements.Keywords:Primidone; Process; Workshop design目录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc326697264 引 言 PAGEREF _Toc326697264 \h 1 HYPERLINK \l _Toc326697265 第一章 设计指导思想和设计原则 PAGEREF _Toc326697265 \h 5 HYPERLINK \l _Toc326697266 1.1 指导思想 PAGEREF _Toc326697266 \h 5 HYPERLINK \l _Toc326697267 1.2 设计原则 PAGEREF _Toc326697267 \h 5 HYPERLINK \l _Toc326697268 1.2.1 厂址选择 PAGEREF _Toc326697268 \h 5 HYPERLINK \l _Toc326697269 1.2.2 总平面设计 PAGEREF _Toc326697269 \h 5 HYPERLINK \l _Toc326697270 1.2.3 工艺流程设计 PAGEREF _Toc326697270 \h 6 HYPERLINK \l _Toc326697271 1.2.4 根据GMP规范，设计应遵循的