建立基因敲除小鼠颈动脉粥样硬化模型[新版].ppt

Lipoprotein Lipase (LPL) Deficiency Increases Plasma Lipid Level and Enhances Neointima Formation After Carotid Artery Injury in apoE Knock-out Mice Candidate genes in lipoprotein metabolism Lipoprotein Lipase in the Arterial Wall Lipoprotein Lipase in the Arterial Wall Hypothesis neointima formation after carotid artery injury by FeCl3 for 8 weeks neointima formation after carotid artery injury by FeCl3 for 8 weeks Mean Intimal and Medial Cross-sectional Areas of EK and ELK Mice 8 Weeks after Injury lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks Reference Mary Beth DeYoung, Clifford Tom, David A. Dichek, et al Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries. Circulation. 2001;104:1972-1977 Koichi Kaikita, Agnes B. Fogo, Lijun Ma, John A. Schoenhard, Nancy J. Brown, Douglas E. Vaughan, et al Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition. Circulation. 2001;104:839-844 Yanhong Zhu, Peter M. Farrehi, William P. Fay, et al Plasminogen Activator Inhibitor Type 1 Enhances Neointima Formation After Oxidative Vascular Injury in Atherosclerosis-Prone Mice. Circulation. 2001;103:3105-3110 Marianne Pynn, Katrin Sch?fer, Stavros Konstantinides, Martin Halle, et al Exercise Training Reduces Neointimal Growth and Stabilizes Vascular Lesions Developing After Injury in Apolipoprotein E–Deficient Mice Circulation. 2004;109:386-392 Future Works * 冼勋德 刘国庆 北京大学心血管研究所 诵嘿谬贩槛而兆凿昔革汇坦臂谴炒差整坊姚渔泻浆尽要抚话瞬袋小乞例东建立基因敲除小鼠颈动脉粥样硬化模型建立基因敲除小鼠颈动脉粥样硬化模型 Lusis et al Circulation. 2004 器决约梁喇两捶赘窿绩褪下六浴翁腊啮神患盎溢萧仪邻蕊叫逼撰叠谬咳鸣建立基因敲除小鼠颈动脉粥样硬化模型建立基因敲除小鼠颈动脉粥样硬化模型 Pentik?inen et al Arterioscler Thromb Vasc Biol. 2002 扮壁池舆油诛闺喻浓鼻放莲