山奈酚通过wnt3abeta-catenin信号通路促进实验性脑缺血小鼠神经功能改善及神经再生-kaempferol promotes neural function improvement and nerve regeneration in experimental cerebral ischemia mice through wnt 3a beta - catenin signaling pathway.docx

万方数据 万方数据 目 录 中文摘要····································································································1 英文摘要····································································································4 英文缩写····································································································8 研究论文 山奈酚通过 Wnt3a/beta-catenin 信号通路促进实验性脑缺血 小鼠神经功能改善及神经再生 前言····································································································9 材料与方法······················································································11 结果··································································································25 附图··································································································26 讨论··································································································31 结论··································································································33 参考文献··························································································34 附录··········································································································38 综述 脑卒中后神经再生的机制和意义················································39 致谢··········································································································50 个人简历··································································································51 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 山奈酚通过 Wnt3a/beta-catenin 信号通路促进实验性脑 缺血小鼠神经功能改善及神经再生 摘 要 目的：脑卒中不仅会造成急性期脑损伤，由于损伤脑组织恢复不佳， 也会引起极高的致残率。由于 rt-PA 过窄的时间窗及可能发生的严重并发 症，溶栓治疗的普及受到很大的限制，因此脑卒中发生后的延迟脑保护治 疗 及 其 对 神 经 功 能 恢 复 的 影 响 越 来 越 受 到 人 们 的 关 注 。 山奈酚 （Kaempferol），属于常见的黄酮类化合物，主要来源于姜科植物山柰 （Kaempferia galangal）的根茎，广泛存在于各种水果、蔬菜及饮料中， 因其具有防癌、抗癌、抗炎、抗氧化、抗菌、抗病毒等多种功效而受到人 们的广泛关注。已有实验证实其在脑卒中的急性期通过抗氧化抗炎等作用 减缓颅内继发性脑损伤，促进预后，但对于这种药物对脑卒中延迟治疗效 果及其是否可改善脑卒中后神经功能的恢复及可能的作用机制却研究甚 少。 成年哺乳动物脑内存在两个能产生大量神经元的生发区，分别为侧脑 室的脑室下带（subvent