氨功能化的MCM-41催化丙二腈及alpha;,beta;-不饱和酮的Michael加成.pdf

DOI: 10.6023/cjoc201305016 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 氨功能化的MCM-41 催化丙二腈与α,β-不饱和酮的Michael 加成 王长春 谢绍雷 解正峰 惠永海* (石油天然气精细化工教育部新疆维吾尔自治区重点实验室 新疆大学化学化工学院 乌鲁木齐 830046) 摘要 利用氨功能化的 MCM-41 催化了丙二腈与 α,β-不饱和酮的 Michael 加成反应，甲醇作溶剂，常 温下反应产率高达 99%，同时得到了一系列高产率的氰基类衍生物，催化剂具有合成简单、环境友好、多 次循环利用等特点. 关键词 氨功能化 MCM-41 ；α,β-不饱和酮；丙二腈；催化；Michael 加成 Michael Addition Reaction of Malononitrile and α,β-unsaturated Ke- tones Catalyzed by Amine Functionalized MCM-41 Wang, Changchun Xie, Shaolei Xie, Zhengfeng Hui, Yonghai* (Key Laboratory of Oil Gas Fine Chemicals, Ministry of Education XinJiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, XinJiang University Urumqi 830046) Abstract Michael addition reaction of α,β-unsaturated ketones and malononitrile that catalyzed by amine functionalized MCM-41 in methanol afforded a series of cyano derivatives with high yield(up to 99%). The products were afforded at room temperature. Moreover, the catalyst was also found to easiness to handle up, friendly environment, and excellent recyclability. Keywords Amine functionalized MCM-41; α,β-unsaturated ketones; malononitrile; catalysis; Michael ad- dition Michael加成是亲核碳负离子对α,β-不饱和羰基类化合物进行1,4-加成的反应，是构筑碳-碳键的重要手段之一 [1-2] [3] [4] [5] ．丙二腈 、β-二羰基类化合物 、硝基烷类 是常见的碳负亲核试剂．其中，丙二腈作为碳负离子亲核试剂， [6] [7] 主要是因为